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dc.contributor.authorDe Brouwer, Geoffrey
dc.contributor.authorFick, Arina
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorWolmarans, De Wet
dc.date.accessioned2018-11-13T13:29:16Z
dc.date.available2018-11-13T13:29:16Z
dc.date.issued2019
dc.identifier.citationDe Brouwer, G. et al. 2019. A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: mapping the way forward. Cognitive affective and behavioral neuroscience, 19(1):1-39. [https://doi.org/10.3758/s13415-018-00653-4]en_US
dc.identifier.issn1530-7026
dc.identifier.issn1531-135X (Online)
dc.identifier.urihttp://hdl.handle.net/10394/31700
dc.identifier.urihttps://link.springer.com/article/10.3758/s13415-018-00653-4
dc.identifier.urihttps://doi.org/10.3758/s13415-018-00653-4
dc.description.abstractRodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or measure to study anxiety- and compulsive-like behaviors or anxiolytic and anticompulsive drug action. However, the test responds variably to a range of pharmacological interventions, and little consensus exists regarding specific methodologies for its execution. Regardless, the test is widely applied to investigate the effects of pharmacological, genetic, and behavioral manipulations on purported behaviors related to the said neuropsychiatric constructs. Therefore, in the present review we attempt to expound the collective translational significance of the MBT. We do this by (1) reviewing burying behavior as a natural behavioral phenotype, (2) highlighting key aspects of anxiety and obsessive–compulsive disorder from a translational perspective, (3) reviewing the history and proof of concept of the MBT, (4) critically appraising potential methodological confounds in execution of the MBT, and (5) dissecting responses of the MBT to various pharmacological interventions. We conclude by underlining that the collective translational value of the MBT will be strengthened by contextually valid experimental designs and objective reporting of dataen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectMarble-burying testen_US
dc.subjectValidityen_US
dc.subjectMethodologyen_US
dc.subjectReviewen_US
dc.subjectAnxietyen_US
dc.subjectObsessive-compulsive disorderen_US
dc.subjectAnimal modelen_US
dc.titleA critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: mapping the way forwarden_US
dc.typeArticleen_US
dc.contributor.researchID11083417 - Harvey, Brian Herbert
dc.contributor.researchID23511990 - De Brouwer, Geoffrey
dc.contributor.researchID12324515 - Wolmarans, Petrus De Wet


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