| dc.contributor.author | Nisar, Madiha | |
| dc.contributor.author | Haynes, Richard K. | |
| dc.contributor.author | Sung, Herman H.-Y. | |
| dc.contributor.author | Puschmann, Horst | |
| dc.contributor.author | Lakerveld, Richard | |
| dc.date.accessioned | 2018-10-11T09:15:14Z | |
| dc.date.available | 2018-10-11T09:15:14Z | |
| dc.date.issued | 2018 | |
| dc.identifier.citation | Nisar, M. et al. 2018. 11-Azaartemisinin cocrystals with preserved lactam : acid heterosynthons. CrystEngComm, 20:1205-1219. [http://dx.doi.org/10.1039/C7CE01875D] | en_US |
| dc.identifier.issn | 1466-8033 (Online) | |
| dc.identifier.uri | http://hdl.handle.net/10394/31354 | |
| dc.identifier.uri | http://dx.doi.org/10.1039/C7CE01875D | |
| dc.description.abstract | 11-Azaartemisinin (11-Aza) is a potent anti-malarial drug more readily able to form cocrystals than its parent compound. 13 new 1 : 1 and 2 : 1 cocrystal phases from 25 mono- and bi-functional acids are reported here in excellent yield and purity by liquid assisted grinding. X-ray structures of several of these cocrystals reveal R22(8) heterosynthons with short OH–O[double bond, length as m-dash]C H-bonds ≤2.60 Å between the 11-Aza lactam and the coformer acid groups. The new phases can show enhanced aqueous solubility of 11-Aza of 3× after 12 h. Notably diastereospecific cocrystal formation can occur, with the DL-mandelic acid system yielding solely the 11-Azaart : D-mandelic acid 1 : 1 product | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | RSC | en_US |
| dc.title | 11-Azaartemisinin cocrystals with preserved lactam : acid heterosynthons | en_US |
| dc.type | Article | en_US |
| dc.contributor.researchID | 22966390 - Haynes, Richard Kingston | |
