Browsing Natural and Agricultural Sciences by Subject "mitochondrial disease"
Now showing items 1-3 of 3
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Differential expression of genes involved in phase two biotransformation in an NDUFS4 deficient mouse model
(North-West University (South Africa), 2021)Mitochondria are involved in a plethora of cellular processes, the most prominent being the production of energy as adenosine triphosphate (ATP) through the oxidative phosphorylation (OXPHOS) system. Dysfunction of the ... -
A metabolomics and biochemical investigation of selected brain regions from Ndufs4 knockout mice
(North-West University (South Africa)North-West University, 2020)Mitochondria, the organelles found throughout the cytoplasm of most eukaryotic cells, have essential functions which have been implicated in the etiology of numerous metabolic and degenerative diseases. The mitochondrial ... -
A metabolomics investigation of selected m.3243A>G mutation phenotypes
(North-West University, 2018)Mitochondrial disease (MD) is a subgroup of inborn errors of metabolism, which can be caused by a mutation in either the nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). One of the most common mtDNA disease causing mutations ...