Browsing Natural and Agricultural Sciences by Subject "Tuberculosis"
Now showing items 1-9 of 9
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The altered fatty acylcarnitines, amino acids and organic acids detected in tuberculosis patient urine
(North-West University (South Africa), Potchefstroom Campus, 2018)Mycobacterium tuberculosis is estimated to infect approximately one-third of the world’s population, which can lead to an active, symptomatic disease called tuberculosis (TB), or to asymptomatic states, often referred ... -
The altered urine metabolome induced by DOTS therapy in pulmonary tuberculosis patients
(North-West University (South Africa), 2023)Metabolomics holds great promise for studying complex diseases like tuberculosis (TB), where treatment outcomes are influenced by a combination of biological, environmental, and social factors. This study aimed to gain a ... -
Characterising the immunometabolic profile of HIV/TB co-infection
(North-West University (South Africa), 2022)The synergy between the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) during co-infection of a host is well established. While this synergy is driven ... -
Characterising tuberculosis treatment success and failure using metabolomics
(North-West University, 2013)Tuberculosis (TB) is one of the deadliest infectious diseases of our time, with 1.4 million deaths globally, recorded in 2010 (3800 deaths a day) by the World Health Organization (WHO). Currently, South Africa ranks third ... -
The effect of sex and HIV on the TB-induced altered sputum metabolome
(North-West University (South Africa), 2023)Various studies have identified TB-induced metabolome variations. However, in most of these studies, the unaccounted-for variation between individual patients is noteworthy. To investigate one potential cause of this ... -
Elucidating the antimicrobial mechanisms of colistin on Mycobacterium tuberculosis using metabolomics
(North-West University, 2018)In 2014, the WHO declared tuberculosis (TB) an epidemic, as an estimated 9 million people suffered from Mtb infection. Today, millions of mortalities are still reported worldwide as a result of this disease. This growing ... -
A metabolomics approach for characterising tuberculosis
(North-West University, 2012)In 2001, the WHO declared tuberculosis (TB) a global emergency, as one third of the world's population suffered from latent M. tuberculosis infection. Today, a decade later, millions of people still die worldwide as a ... -
A metabolomics approach investigating the functionality of the ESX-1 gene cluster in mycobacteria
(North-West University, 2015)Tuberculosis (TB) claims the lives of millions of individuals each year, and is consequently the world’s second-most deadly infectious disease after acquired immune deficiency syndrome (AIDS), responsible for 1.4 million ... -
The role of the ESX–3 gene cluster and iron on mycobacterial viability
(North-West University, 2013)According to the World Health Organization (WHO), M. tuberculosis, the causative agent of TB, accounts for approximately 1.7 million deaths annually. Further contributing causes to the worldwide TB incidence, is the ...