Browsing Natural and Agricultural Sciences by Subject "Skeletal muscle"
Now showing items 1-3 of 3
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Investigating tissue-specificity in a mouse model of Leigh Syndrome using metabolomics
(North-West University (South Africa), 2022)Mitochondrial disease (MD) is one of the most challenging groups of inborn disorders featuring a tissue-specific vulnerability, governed by largely unknown mechanisms. The value of metabolomics in multi-systemic MD ... -
Metabolomics and biochemical evaluation of skeletal muscle from Ndufs4 knockout mice
(North-West University (South Africa), 2019)The dysfunction of mitochondrial complex I (CI) impedes the most efficient mechanism feeding electrons into the respiratory chain (RC) — a system that, together with ATP synthase (CV), is responsible for the majority of ... -
Quantification of coenzymeQ10 in South African pediatric patients with electron transport chain deficiencies
(North-West University (South Africa), Potchefstroom Campus, 2015)CoenzymeQ10 (CoQ10) is an important component of the mitochondrial electron transport chain (ETC). Co010 deficiency mainly affects children, and patients present with heterogeneous clinical phenotypes. Patients frequently ...