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Radio-labelling as a tool to investigate the absorption and bio-distribution of selected antimalarial drugs
(2014)
Previous studies have shown that the formulation of an active pharmaceutical ingredient (API) entrapped in the Pheroid® (Pheroid for simplification) delivery system enhances absorption of the API, suppresses its metabolism, ...
The synthesis and evaluation of phenoxymethylcaffeine analogues as inhibitors of monoamine oxidase
(North-West University, 2010)
Purpose: Monoamine oxidase (MAO) plays a key role in the treatment of Parkinson's disease (PD), since it is the major enzyme responsible for the catabolism of dopamine in the substantia nigra of the brain. Inhibition of ...