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The modulating effect of myo-inositol and other antidepressants on the mRNA levels and protein expression of selected subcellular enzymes
(North-West University, 2005)
Myo-lnositol (mIns), a natural component of the human diet and essential precursor of
several signalling pathways, including that of G protein-coupled receptors, has also been
shown to be effective in the treatment of ...
The role of myo-inositol in G-protein coupled receptor-mediated sub-cellular transduction mechanisms in neuronal cell lines
(North-West University, 2003)
myo-lnositol (ml), a simple polyol isomer of glucose, is an important osmolyte in the brain and a precursor of the phosphatidyl inositol metabolic pathway. It is known to facilitate various cellular events such as membrane ...
Cardiovascular function and psychological distress in urbanised black South Africans : the SABPA study
(North-West University, 2009)
Motivation: Cardiovascular disease (CVD) is one of the leading causes of death worldwide, with the greatest mortality rates occurring in low and middle income countries. The increase in the prevalence of risk factors such ...
The role of the NO-cGMP pathway as a putative target in antidepressant action
(North-West University, 2004)
Depressive disorders are among the most frequent psychiatric diseases in the Western world with prevalence between 9% and 18%. Poor compliance and inappropriate antidepressant discontinuation invokes long-term morbidity, ...
Regional neurochemical characterization of the flinders sensitive line rat with regard to gaba and cholinergic signalling pathways
(North-West University, 2008)
Despite their acknowledged efficacy, currently available antidepressants still demonstrate undesirable side effects, shortfalls in effectiveness and a delayed onset of action. All these agents act via monoaminergic mechanisms, ...
The modulatory effects of sildenafil and the cholinergic system on antidepressant action in a rat model of depression
(North-West University, 2006)
Sildenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor, is registered for the treatment of male erectile dysfunction (Viagra®) and pulmonary hypertension (Revatio®) in the United States. PDE5 is found in the ...
Overview of antidepressant usage and cost 2004 until 2006
(North-West University, 2007)
Depression has an increasingly significant economic impact and quality of life burden on patients, employers and third party payers worldwide (Hylan et a/., 1998:53). Current projections indicate that the global burden of ...
The narratives of people who suffer from depression
(North-West University (South-Africa), 2001)
The purpose of this study was to examine and compare the narratives of depressed and non-depressed
people in the light of the principles of a narrative approach to therapy which were
provided by a supposition matrix. A ...