Browsing Health Sciences by Subject "Prepulse inhibition"
Now showing items 1-5 of 5
-
Behavioural, neurochemical, inflammatory and mitichondrial markers following social isolation rearing in rats before and after selected deug intervention
(North-West University, 2012)Purpose: Schizophrenia is a progressive degenerative illness that has been causally linked to mitochondrial dysfunction, oxidative stress and a pro-inflammatory state. Social isolation rearing (SIR) in rats models the ... -
Behavioural, pharmacological and neurochemical studies of social isolation rearing in rats
(North-West University, 2007)Schizophrenia affects approximately 1% of the population. Despite marked improvement in drug treatment, 20% of patients remain treatment resistant while motor side effects hamper compliance and outcome. A better understanding ... -
Bio-behavioral characterisation of a selective α2C-receptor antagonist in animal models of schizophrenia and depression
(North-West University (South Africa) , Potchefstroom Campus, 2016)Purpose: Schizophrenia and depression are neuropsychiatric disorders characterised by affective and cognitive dysfunction and are associated with altered monoaminergic and neurotrophic function. Social isolation rearing ... -
Development and validation of an animal model of treatment-resistant depression with psychotic features
(North-West University (South-Africa), 2021)Major depression (MD) affects up to 17% of the global population. While effective treatments for MD exist, an underlying interaction between genetic propensity and chronic and/or early life adversity may render these drugs ... -
Oxidative status in rats exposed to social isolation rearing : behavioral pharmacology studies and relevance for schizophrenia
(North-West University, 2009)PURPOSE: Psychotic (positive) symptoms are the most distinctive feature of schizophrenia, although negative symptoms such as emotional flattening, social withdrawal and cognitive disturbances are the most treatment resistant ...