Browsing Health Sciences by Subject "Imipramine"
Now showing items 1-4 of 4
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Development and validation of an animal model of treatment resistant depression
(North-West University (South Africa) , Potchefstroom Campus, 2017)The current investigation focused on the development and validation of an animal model of treatment resistant depression (TRD). In addition, an in-depth review of biomarkers of depression was included which aimed to identify ... -
The modulating effect of myo-inositol and other antidepressants on the mRNA levels and protein expression of selected subcellular enzymes
(North-West University, 2005)Myo-lnositol (mIns), a natural component of the human diet and essential precursor of several signalling pathways, including that of G protein-coupled receptors, has also been shown to be effective in the treatment of ... -
The role of myo-inositol in G-protein coupled receptor-mediated sub-cellular transduction mechanisms in neuronal cell lines
(North-West University, 2003)myo-lnositol (ml), a simple polyol isomer of glucose, is an important osmolyte in the brain and a precursor of the phosphatidyl inositol metabolic pathway. It is known to facilitate various cellular events such as membrane ... -
The role of the NO-cGMP pathway as a putative target in antidepressant action
(North-West University, 2004)Depressive disorders are among the most frequent psychiatric diseases in the Western world with prevalence between 9% and 18%. Poor compliance and inappropriate antidepressant discontinuation invokes long-term morbidity, ...