Browsing Health Sciences by Subject "Frontal cortex"
Now showing items 1-6 of 6
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Behavioral, neuroendocrine and neurochemical studies on agomelatine in social isolation reared rats
(North-West University (South Africa) , Potchefstroom Campus, 2015)1. Introduction. There is currently a large body of evidence suggesting that stressful early life experiences, such as maternal separation and social isolation, may play a role in the development of major depressive disorder ... -
Behavioural, pharmacological and neurochemical studies of social isolation rearing in rats
(North-West University, 2007)Schizophrenia affects approximately 1% of the population. Despite marked improvement in drug treatment, 20% of patients remain treatment resistant while motor side effects hamper compliance and outcome. A better understanding ... -
A bio-behavioural investigation into the role of the cholinergic system in stress
(North-West University, 2006)Posttraumatic stress disorder (PTSD) is an anxiety disorder that may follow exposure to severe emotional trauma and presents with various symptoms of anxiety, hyperarousal and cognitive anomalies. Interestingly, only ... -
Investigating the role of AMPAkines in an animal model of post-traumatic stress disorder (PTSD)
(North-West University, 2008)Post-traumatic stress disorder (PTSD) is a severe anxiety disorder affecting cognitive function. 1 in 4 individuals exposed to a life-threatening event may develop PTSD, which is characterised by symptoms of hyperarousal, ... -
A pharmacokinetic-pharmacodynamic relationship study between GABA-ergic drugs and anxiety levels in an animal model of PTSD
(North-West University, 2005)Posttraumatic stress disorder (PTSD) is classified as an anxiety disorder and the characteristic symptoms (re-experiencing, avoidance as well as numbing of general responsiveness and hyperarousal) of this disorder develop ... -
Regional neurochemical characterization of the flinders sensitive line rat with regard to gaba and cholinergic signalling pathways
(North-West University, 2008)Despite their acknowledged efficacy, currently available antidepressants still demonstrate undesirable side effects, shortfalls in effectiveness and a delayed onset of action. All these agents act via monoaminergic mechanisms, ...