Browsing Health Sciences by Subject "Dopamine"
Now showing items 1-7 of 7
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Dopaminergic and serotonergic modulation of reward appraisal in the zebrafish (Danio rerio)
(North-West University (South-Africa), 2020)Obsessive-compulsive disorder (OCD)1 is a chronic and debilitating neuropsychiatric condition affecting 1 – 3% of the world population. The condition is characterized by two main symptom cohorts namely recurrent, distressing ... -
An investigation into the effects of Sceletium tortuosum in a methamphetamine addiction model in Sprague Dawley rats
(North-West University (South-Africa), 2021)Background: Methamphetamine (MA), globally known as “crystal meth”, is a highly addictive psychostimulant, which can be easily synthesized by using over the counter medicine and common household items. It induces intense ... -
Persistent behavioural phenotypes in the deer mouse and its response to serotonergic and dopaminergic intervention
(North-West University (South-Africa), 2019)Obsessive compulsive disorder (OCD)1 is a debilitating psychiatric disorder that presents with intrusive thoughts (obsessions) and repetitive ritualistic behaviour (compulsions) as main symptoms. Selective reuptake inhibitors ... -
The synthesis and evaluation of 1-methyl-3-pyrrolines and 1-methylpyrroles as substrates and inhibitors of monoamine oxidase B
(North-West University, 2007)Very little is known about why and how the Parkinson's disease (PD) neurodegenerative process begins and progresses. In the course of developments for treatment of PD, the discovery of the inhibition of monoamine oxidase ... -
The synthesis and evaluation of dual inhibitors of monoamine oxidase and catechol-O-methyltransferase
(North-West University (South Africa), Potchefstroom Campus, 2018)Parkinson’s disease is the second most prevalent neurodegenerative disorder after Alzheimer’s disease. Parkinson’s disease is a debilitating, incurable, bradykinetic disorder which seriously inhibits a patient’s quality ... -
Synthesis and evaluation of nitrocatechol derivatives of chalcone as inhibitors of monoamine oxidase and catechol-O-methyltransferase
(North-West University (South-Africa). Potchefstroom Campus, 2019)Parkinson’s disease is a progressive neurological movement disorder that worsens with age. Parkinson’s disease is still the most frequent neurodegenerative disorder after Alzheimer’s disease. There is no known cause of ... -
Synthesis and evaluation of sesamol derivatives as inhibitors of monoamine oxidase
(2014)Parkinson’s disease is an age-related neurodegenerative disorder. The major symptoms of Parkinson’s disease are closely linked to the pathology of the disease. The main pathology of Parkinson’s disease consists of the ...