Browsing Health Sciences by Author "Rheeders, M."
Now showing items 1-6 of 6
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Blood levels of selective antiretroviral drugs over a period of time, in Sprague-Dawley rats
Du Plooy, Michael (North-West University, 2008)Selective antiretroviral (ARV) drugs are primarily metabolized by cytochrome P450 (CYP) enzymes, characteristically predisposed to variation, and are therefore primarily responsible for ARV pharmacokinetic variability and ... -
The pharmacokinetic interaction between cyclosporine and methoxsalen
Bouwer, Máralien (North-West University, 2003)Cyclosporine forms the cornerstone of therapy to prevent rejection after organ transplantation. However, the clinical use of the drug is compromised by a narrow therapeutic window and a wide inter- and intra-individual ... -
A pharmacokinetic-pharmacodynamic relationship study between GABA-ergic drugs and anxiety levels in an animal model of PTSD
Myburgh, Jacolene (North-West University, 2005)Posttraumatic stress disorder (PTSD) is classified as an anxiety disorder and the characteristic symptoms (re-experiencing, avoidance as well as numbing of general responsiveness and hyperarousal) of this disorder develop ... -
A pilot investigation on plasma tenofovir levels and possible side effects in HIV-infected women
Mulubwa, Mwila (2015)Tenofovir disoproxil fumarate (TDF) is a nucleotide reverse transcriptase inhibitor and a prodrug of tenofovir (TFV). It is the currently recommended first line combination treatment of human immunodeficiency virus (HIV) ... -
Population pharmacokinetic and pharmacodynamic study of efavirenz in HIV–1–infected children treated with first line antiretroviral therapy in South Africa
Viljoen, Michelle (North-West University, 2011)Highly active antiretroviral therapy (HAART) has improved the life expectancy of HIV–1–infected patients dramatically since it was launched in 1996, but there are still many challenges in the provision of HAART, especially ... -
Therapeutic drug monitoring of gentamicin and amikacin in hospitalised patients in a private hospital, Western Cape
Du Toit, Mariëtte (North-West University (South-Africa)., 2019)Background: The burden of resistant bacteria is increasing and to ensure optimal treatment with the antibiotics currently available, therapeutic drug monitoring should be performed when prescribing aminoglycosides. ...