Browsing Electronic Theses and Dissertations (ETDs) by Subject "Catechol-O-methyltransferase"
Now showing items 1-3 of 3
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Discovery of catechol-O-methyltransferase inhibitors through virtual screening
(North-West University (South Africa) , Potchefstroom Campus, 2016)BACKGROUND AND RATIONALE: Parkinson’s disease (PD) is a progressive neurodegenerative disease that is caused by the death of dopaminergic neurons in the substantia nigra resulting in a loss of dopamine in the striatum. ... -
The synthesis and evaluation of dual inhibitors of monoamine oxidase and catechol-O-methyltransferase
(North-West University (South Africa), Potchefstroom Campus, 2018)Parkinson’s disease is the second most prevalent neurodegenerative disorder after Alzheimer’s disease. Parkinson’s disease is a debilitating, incurable, bradykinetic disorder which seriously inhibits a patient’s quality ... -
Synthesis and evaluation of nitrocatechol derivatives of chalcone as inhibitors of monoamine oxidase and catechol-O-methyltransferase
(North-West University (South-Africa). Potchefstroom Campus, 2019)Parkinson’s disease is a progressive neurological movement disorder that worsens with age. Parkinson’s disease is still the most frequent neurodegenerative disorder after Alzheimer’s disease. There is no known cause of ...