Browsing Electronic Theses and Dissertations (ETDs) by Subject "Amorphous"

Now showing items 1-7 of 7

    • Amorphism and polymorphism of azithromycin 

      Odendaal, Roelf Willem (North-West University, 2012)
      Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ...

    • The effect of solid-state forms on the topical delivery of roxithromycin 

      Csongradi, Candice (2015)
      The skin is a very accessible and convenient route of administration for topical and systemic drugs (Williams, 2003:1). The only problem most formulators face is overcoming the barrier function of the stratum corneum, which ...

    • Investigation of the stabilising effects of niosomes on the amorphous forms of roxithromycin 

      Boshoff, Suné (North-West University (South Africa), Potchefstroom Campus, 2018)
      The first aim of this research study was to determine the effect of the excipients used in the typical niosome preparation on the solid-state nature of three solid-state forms of roxithromycin. The second aim was to ascertain ...

    • The physico-chemical properties and recrystallisation kinetics of selected amorphous active ingredients 

      Milne, Marnus (North-West University (South Africa) , Potchefstroom Campus, 2015)
      During the last two to three decades the application of amorphous solid-state forms within the pharmaceutical industry gained much interest. The rationale for this heightened interest is the increased aqueous solubility, ...

    • The physico–chemical properties of spiramycin and clarithromycin 

      Van Eeden, Rodé (2012)
      In most cases, organic materials exist in the solid phase as polymorphs, solvatomorphs or amorphous forms. Physico-chemical properties in the solid-state are all affected primarily in terms of dissolution, solubility, ...

    • Roxithromycin : a solubility and stability study 

      Van Niekerk, Elzet (North-West University, 2011)
      Roxithromycin is a semi-synthetic, macrolide antibiotic, derived from erythromycin A. It acts as a bacteriostatic drug at low concentrations and a bactericidal drug at high concentrations. It binds to the 50S subunit of ...

    • Stability of amorphous azithromycin in a tablet formulation 

      Obulapuram, Prasanna Kumar (2014)
      It is a well-known fact that drugs can exist in different solid-state forms. These solid-state forms can be either crystalline or amorphous. Furthermore, significant differences are identified between the different solid-state ...