dc.contributor.author | Ebenhan, Thomas | |
dc.contributor.author | Zeevaart, Jan Rijn | |
dc.contributor.author | Mokaleng, Botshelo Brenda | |
dc.contributor.author | Venter, Jacobus Daniel | |
dc.contributor.author | Kruger, Hendrik Gert | |
dc.date.accessioned | 2017-10-11T06:08:24Z | |
dc.date.available | 2017-10-11T06:08:24Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Ebenhan, T. et al. 2017. Preclinical assessment of a 68Ga-DOTA-functionalized depsipeptide as a radiodiagnostic infection imaging agent. Molecules, 22(9): # 1403. [https://doi.org/10.3390/molecules22091403] | en_US |
dc.identifier.issn | 1420-3049 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/25775 | |
dc.identifier.uri | http://www.mdpi.com/1420-3049/22/9/1403 | |
dc.identifier.uri | https://doi.org/10.3390/molecules22091403 | |
dc.description.abstract | The study assessed a radiolabeled depsipeptide conjugate (68Ga-DOTA-TBIA101) for its potential as an imaging agent targeting infection or infection-associated inflammation. 68Ga-labeled DOTA-TBIA101 imaging was performed in (NZR1) healthy rabbits; (NZR2) rabbits bearing muscular sterile inflammation and Staphylococcus aureus (SA) infection; and (NZR3) rabbits infected with Mycobacterium tuberculosis (MTB) combined with a subcutaneous scruff infection of SA in the same animal. All animals were imaged using a PET/CT scanner at 5 and 60 min post injection. Images showed elevated accumulation of 68Ga-DOTA-TBIA101 in the sterile muscular inflammation site (T/NT ratio = 2.6 ± 0.37 (5 min) and 2.8 ± 2.3 (60 min)) and muscles infected with MTB (T/NT ratio = 2.6 ± 0.35 (5 min) and 2.8 ± 0.16 (60 min)). The findings suggest that 68Ga-DOTA-TBIA101-PET/CT may detect MTB-associated inflammation, although more foundational studies need to be performed to rationalize the diagnostic value of this technique | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.subject | DOTA-TBIA101 | en_US |
dc.subject | Depsipeptides | en_US |
dc.subject | Infection | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Tuberculosis | en_US |
dc.subject | 68Ga/68Ge generator | en_US |
dc.subject | PET/CT imaging | en_US |
dc.title | Preclinical assessment of a 68Ga-DOTA-functionalized depsipeptide as a radiodiagnostic infection imaging agent | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 16951484 - Zeevaart, Jan Rijn | |