Signaling responses after varying sequencing of strength and endurance training in a fed state
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Date
Authors
Jones, Thomas W.
Howatson, Glyn
Walshe, Ian H.
Hamilton, David L.
Russell, Mark
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Volume Title
Publisher
Human Kinetics
Abstract
Purpose:
To compare anabolic signaling responses to differing sequences of concurrent strength and endurance training in a fed state.
Methods:
Eighteen resistance-trained men were randomly assigned to the following experimental conditions: strength training (ST), strength followed by endurance training (ST-END), or endurance followed by strength training (END-ST). Muscle tissue samples were taken from the vastus lateralis before each exercise protocol, on cessation of exercise, and 1 h after cessation of strength training. Tissue was analyzed for total and phosphorylated (p-) signaling proteins linked to the mTOR and AMPK networks.
Results:
Strength-training performance was similar between ST, ST-END, and END-ST. p-S6k1 was elevated from baseline 1 h posttraining in ST and ST-END (both P < .05). p-4E-BP1 was significantly lower than baseline post-ST (P = .01), whereas at 1 h postexercise in the ST-END condition p-4E-BP1 was significantly greater than postexercise (P = .04). p-ACC was elevated from baseline both postexercise and 1 h postexercise (both P < .05) in the END-ST condition. AMPK, mTOR, p38, PKB, and eEF2 responded similarly to ST, ST-END, and END-ST. Signaling responses to ST, ST-END, and END were largely similar. As such it cannot be ascertained which sequence of concurrent strength and endurance training is most favorable in promoting anabolic signaling.
Conclusions:
In the case of the current study an acute bout of concurrent training of differing sequences elicited similar responses of the AMPK and mTOR networks
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Citation
Jones, T.W. et al. 2016. Signaling responses after varying sequencing of strength and endurance training in a fed state. International journal of sports physiology and performance, 11:868-875. [https://doi.org/10.1123/ijspp.2015-0534]