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Polyunsaturated fatty acid status in treated isovaleric acidemia patients
(Springer Nature, 2016)
BACKGROUND/OBJECTIVES: Nutritional deficiencies are frequently observed when treating patients with inborn errors of
metabolism due to an unbalanced diet. Thus far, patients with isovaleric acidemia (IVA) who adhere to a ...
A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS)
(Elsevier, 2019)
We used a comprehensive metabolomics approach to study the altered urinary metabolome of two mitochondrial myopathy, encephalopathy lactic acidosis and stroke like episodes (MELAS) cohorts carrying the m.3243A>G mutation.
The ...
Fatty acid metabolome extraction from mycobacterial cells for GC-MS metabolomics analysis
(Humana, 2019)
Metabolomics is becoming an increasingly popular research tool for identifying new biomarkers, which can, among other applications, be applied to elucidate various microbial growth and virulence mechanisms. Since the lipid ...
Systemic and organ specific metabolic variation in metallothionein knockout mice challenged with swimming exercise
(Springer, 2013)
Metallothioneins (MTs) are ubiquitous, multifunctional
proteins with key roles in metal homeostasis and
redox regulation. Their involvement in cellular energy
metabolism is evident from the observation that metallothi ...
The application of metabolomics toward pulmonary tuberculosis research
(Elsevier, 2019)
In the quest to identify novel biomarkers for pulmonary tuberculosis (TB), high-throughput systems biology approaches such as metabolomics has become increasingly widespread. Such biomarkers have not only successfully been ...
Urinary metabolites and their link with premature arterial stiffness in black boys: the ASOS study
(Karger, 2018)
Background and Aims: Black boys (6–8 years of age) were shown to have higher pulse wave
velocity with potential early vascular compromise. We aimed to compare predefined urinary
metabolites in black and white boys to ...
Miniaturized 1H-NMR method for analyzing limited-quantity samples applied to a mouse model of Leigh disease
(Springer, 2018)
Introduction
The analysis of limited-quantity samples remains a challenge associated with mouse models, especially for multi-platform metabolomics studies. Although inherently insensitive, the highly specific characteristics ...
Metabolomics as an approach to characterise the contrasting roles of CCR5 in the presence and absence of disease
(MDPI, 2020)
Chemokine receptors such as C-C chemokine receptor 5 (CCR5) are activated through interaction with their ligands and are well known for their role in chemotaxis and signal transduction. While serving these roles, cellular ...
Metabolomics describes previously unknown toxicity mechanisms of isoniazid and rifampicin
(Elsevier, 2020)
Isoniazid and rifampicin are well-known anti-mycobacterial agents and are widely used to treat pulmonary tuberculosis (TB) as part of the combined therapy approach, recommended by the World Health Organization. The ingestion ...
Metabolic characterization of tuberculous meningitis in a South African paediatric population using 1H NMR metabolomics
(Elsevier, 2020)
Objective
To better characterize the cerebrospinal fluid (CSF) metabolic profile of tuberculous meningitis (TBM) cases using a South African paediatric cohort.
Methods
1H NMR metabolomics was used to analyse the CSF ...