Browsing Faculty of Natural and Agricultural Sciences by Subject "Parkinson’s disease"
Now showing items 1-8 of 8
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An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson's disease
(Springer, 2015)A rostral brainstem structure, the pedunculopontine nucleus (PPN), is severely affected by Parkinson’s disease (PD) pathology and is regarded a promising target for therapeutic deep-brain stimulation (DBS). However, ... -
Attenuation of endoplasmic reticulum stress, impaired calcium homeostasis, and altered bioenergetic functions in MPP+-Exposed SH-SY5Y cells pretreated with rutin
(Springer, 2019)Parkinson’s disease (PD) is a common neurodegenerative disorder that affects approximately 1% of the population over the age of 65 years. While treatment options for PD are limited, reports show that plant-derived bioactive ... -
Curcumin rescues a PINK1 knock down SH-SY5Y cellular model of Parkinson’s disease from mitochondrial dysfunction and cell death
(Springer, 2017)Parkinson’s disease (PD) is a neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra. Mutations in the PINK1 gene result in an autosomal recessive form of early-onset PD. ... -
Investigating the potential neuroprotective effects of statins on DNA damage in mouse striatium
(Elsevier, 2008)We investigated the protective effect of pravastatin, simvastatin and atorvastatin on striatal DNA damage as a potential method to conserve and protect the nigrostriatal neurons. C57Bl/J6 mice were treated with combinations ... -
A molecular analysis of the GBA gene in Caucasian South Africans with Parkinson's disease
(Wiley, 2017)Background The molecular basis of Parkinson's disease in South African population groups remains elusive. To date, substitutions in the GBA gene are the most common large-effect genetic risk factor for Parkinson's disease. ... -
Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats
(Springer, 2016)We previously reported a loss of cholinergic neurons within the pedunculopontine tegmental nucleus (PPTg) in rats that had been intra-nigrally lesioned with the proteasomal inhibitor lactacystin, with levels of neuronal ... -
Synthesis and evaluation of chromone derivatives as inhibitors of monoamine oxidase
(Springer, 2019)Based on reports that chromone compounds are good potency inhibitors of monoamine oxidase (MAO), the present study evaluates the effect of substitution with flexible side chains on the 3 position on MAO inhibition potency. ... -
Temporal-spatial profiling of pedunculopontine galanin-cholinergic neurons in the lactacystin rat model of Parkinson’s disease
(Springer, 2017)Parkinson’s disease (PD) is conventionally seen as resulting from single-system neurodegeneration affecting nigrostriatal dopaminergic neurons. However, accumulating evidence indicates multi-system degeneration and ...