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A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression
(Elsevier, 2011)
Major depressive disorder (MDD) and diabetes mellitus type II (T2DM) are two of the major health challenges of our time. It has been shown that MDD and T2DM are highly co-morbid, and recent work has proposed a bi-directional ...
Quantitative hippocampal structural changes following elctroconvulsive seizure treatment in a rat model of depression
(Wiley, 2012)
Objective: The pathophysiology of depression and the effects of antidepressant
treatment are hypothesized to be related to hippocampal structural
changes. This study aims to investigate the effect of electroconvulsive ...
Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase
(Elsevier, 2012)
Methylene blue (MB) has been shown to act at multiple cellular and molecular targets and as a result
possesses diverse medical applications. Among these is a high potency reversible inhibition of monoamine
oxidase A ...
Selectively bred rodents as models of depression and anxiety
(Springer, 2012)
Stress related diseases such as depression and anxiety have a high degree of co morbidity, and represent one of the greatest therapeutic challenges for the twenty-first century. The present chapter will summarize existing ...
The schizophrenia and bipolar disorder associated BRD1 gene is regulated upon chronic restraint stress
(Elsevier, 2012)
Recent genetic evidence has implicated the bromodomain containing 1 gene (BRD1) with brain development and susceptibility to Schizophrenia and Bipolar Disorder. The BRD1 protein, which is essential for acetylation of histone ...
Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats
(Elsevier, 2017)
The rapid and sustained antidepressant properties of ketamine provide evidence of the importance of the glutamatergic system in the neurobiology of depression. The antidepressant-like effects of ketamine are dependent on ...
Differential expression of postsynaptic NMDA and AMPA receptor subunits in the hippocampus and prefrontal cortex of the flinders sensitive line rat model of depression
(Wiley, 2016)
Glutamatergic abnormalities have recently been implicated in the pathophysiology of depression, and the ionotropic glutamate receptors in particular have been suggested as possible underlying molecular determinants. The ...
Neurovascular plasticity of the hippocampus one week after a single dose of ketamine in genetic rat model of depression
(Wiley, 2016)
Glutamatergic system and the structural plasticity hypothesis are principal components for rapid and sustained antidepressant effects of novel antidepressant therapeutics. This study represents the first investigation of ...
Sex-dependent behavior, neuropeptide profile and antidepressant response in rat model of depression
(Elsevier, 2018)
A plethora of animal models of depression is described in the literature, aiming at mimicking different aspects of depression. Understanding the link between depression and stress has been and remains a major focus area ...
Potential involvement of serotonergic signaling in ketamine's antidepressant actions: a critical review
(Elsevier, 2016)
A single i.v. infusion of ketamine, classified as an N-methyl-d-aspartate (NMDA) receptor antagonist, may alleviate depressive symptoms within hours of administration in treatment resistant depressed patients, and the ...