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Methylene blue analogues with marginal monoamine oxidase inhibition retain antidepressant-like activity
(ACS, 2018)
Methylene blue (MB) possesses diverse medical applications. Among these, MB presents with antidepressant-like effects in animals and has shown promise in clinical trials for the treatment of mood disorders. As an antidepressant, ...
Maternal high-fat diet programs offspring emotional behavior in adulthood
(Elsevier, 2018)
Prenatal exposure to high-fat diet (HFD) might predispose offspring to develop metabolic and mental disorders later in life. Insight into the molecular and behavioral consequences of maternal HFD on offspring is sparse but ...
Methylene blue and its analogues as antidepressant compounds
(Springer, 2017)
Methylene Blue (MB) is considered to have diverse medical applications and is a well-described treatment for methemoglobinemias and ifosfamide-induced encephalopathy. In recent years the focus has shifted to MB as an ...
The impact of a therapeutic exercise intervention on depression and body self-image in HIV-positive women in sub-Saharan Africa
(Dove Press, 2018)
Attitudes, responses, and reactions of HIV-positive women in three sub-Saharan African regions toward a therapeutic exercise intervention, aimed to determine the presence of depression and low body self-image, were captured. ...
A high-fat diet exacerbates depressive-like behavior in the Flinders Sensitive Line (FSL) rat, a genetic model of depression
(Elsevier, 2011)
Major depressive disorder (MDD) and diabetes mellitus type II (T2DM) are two of the major health challenges of our time. It has been shown that MDD and T2DM are highly co-morbid, and recent work has proposed a bi-directional ...
Depressive symptoms and sub-clinical atherosclerosis in Africans: role of metabolic syndrome, inflammation and sympathoadrenal function
(Elsevier, 2011)
Depressive symptoms have been consistently associated with sub-clinical atherosclerosis and future risk of coronary heart disease events. However, the pathways linking depression and coronary atherosclerosis are poorly ...
An inhibitor of cAMP-dependent protein kinase induces behavioural and neurological antidepressant-like effects in rats
(Elsevier, 2011)
Although it is well established that cyclic adenosine monophosphate (cAMP) signalling via cAMPdependent protein kinase (PKA)within neurons plays an important role in depression and antidepressant treatment, the importance ...
Selectively bred rodents as models of depression and anxiety
(Springer, 2012)
Stress related diseases such as depression and anxiety have a high degree of co morbidity, and represent one of the greatest therapeutic challenges for the twenty-first century. The present chapter will summarize existing ...
Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats
(Elsevier, 2017)
The rapid and sustained antidepressant properties of ketamine provide evidence of the importance of the glutamatergic system in the neurobiology of depression. The antidepressant-like effects of ketamine are dependent on ...
Ketamine and rapidly acting antidepressants: breaking the speed of sound or light?
(Sage, 2018)
There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key ...