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Antiplasmodial activity and cytotoxicity of 10β-aminoquinolinylethylethers of artemisinin
(Thieme, 2013)
Each year roughly 800 000 people die of malaria, with 95% being African children. The shortcomings of the current drugs and the emergence of P. falciparum resistance to the artemisinin class of compounds warrant the search ...
Selected furanochalcones as inhibitors of monoamine oxidase
(Elsevier, 2013)
The validity of the chalcone scaffold for the design of inhibitors of monoamine oxidase has previously
been illustrated. In a systematic attempt to investigate the effect of heterocyclic substitution on the
monoamine ...
Solution-mediated phase transformation of different roxithromycin solid-state forms: implications on dissolution and solubility
(Elsevier, 2013)
The objective of this study was to describe the solid-state forms in which roxithromycin may exist and
the significant influence of solution-mediated phase transformation on the dissolution and solubility
behavior of ...
The effect of a multidisciplinary physical activity intervention on the body composition and physical fitness of obese children
(Minerva Medica, 2013)
AIM:
The aim was to determine the effect of a physical activity, diet, and behaviour modification intervention of 13 weeks, 3x per week for 60 minutes on the body composition and physical fitness of overweight and obese ...
The use of heart rates and graded maximal test values to determine rugby union game intensities
(Lippincott, Williams & Wilkins, 2013)
The aim of this study was to determine the intensities of university rugby union games using heart rates and graded maximal test values. Twenty-one rugby players performed a standard incremental maximal oxygen uptake ...
Production of high specific activity 195mPt‐cisplatinum at South African Nuclear Energy Corporation for Phase 0 clinical trials in healthy individual subjects
(Wiley, 2013)
Platinum agents continue to be the main chemotherapeutic agents used in the first-line and second-line treatments of cancer
patients. It is important to fully understand the biological profile of these compounds in order ...
The adenosine A2A antagonistic properties of selected C8-substituted xanthines
(Elsevier, 2013)
The adenosine A2A receptor is considered to be an important target for the development of new therapies
for Parkinson’s disease. Several antagonists of the A2A receptor have entered clinical trials for this purpose
and ...
Testosterone and acute stress are associated with fibrinogen and Von Willebrand factor in African men: the SABPA study
(Elsevier, 2013)
Background: Low testosterone, acute and chronic stress and hypercoagulation are all associated with hypertension
and hypertension-related diseases. The interaction between these factors and future risk for coronary ...