Browsing Faculty of Health Sciences by Subject "Social isolation rearing"
Now showing items 1-6 of 6
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The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical n-methyl-d-aspartate and d1 receptor binding in rats
(Elsevier, 2010)Glutamate and dopamine disturbances are implicated in frontal cortical dysfunction in schizophrenia. Little, however, is known about the nature of dopamine D1 and N-methyl-d-aspartate (NMDA) receptor interactions in the ... -
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
(Springer, 2013)Schizophrenia is causally associated with early-life environmental stress, implicating oxidative stress in its pathophysiology. N-acetyl cysteine (NAC), a glutathione precursor and antioxidant, is emerging as a useful ... -
Neurodevelopmental animal models reveal the convergent role of neurotransmitter systems, inflammation, and oxidative stress as biomarkers of schizophrenia: implications for novel drug development
(ACS, 2015)Schizophrenia is a life altering disease with a complex etiology and pathophysiology, and although antipsychotics are valuable in treating the disorder, certain symptoms and/or sufferers remain resistant to treatment. ... -
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment
(Elsevier, 2012)Schizophrenia is associated with increased oxidative stress, although the source of this redox disequilibrium requires further study. Altered tryptophan metabolism has been described in schizophrenia, possibly linked to ... -
Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine
(Elsevier, 2013)Apart from altered dopamine (DA) function, schizophrenia displays mitochondrial and immune-inflammatory abnormalities, evidenced by oxidative stress, altered kynure nine metaboli sm and cytokine release . N-acetyl cysteine ... -
Studies into the anxiolytic actions of agomelatine in social isolation reared rats: role of corticosterone and sex
(Sage, 2018)Anxiety disorders are severely disabling, while current pharmacological treatments are complicated by delayed onset, low remission rates and side-effects. Sex is also noted to contribute towards illness severity and treatment ...