Browsing Faculty of Health Sciences by Subject "Cytotoxicity"
Now showing items 1-10 of 16
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Antimalarial activity of 10-alkyl/aryl esters and – aminoethylethers of artemisinin
(Elsevier, 2013)A series of n-alkyl/aryl esters were synthesized and their in vitro antiplasmodial activity was measured alongside that of previously synthesized aminoethylethers of artemisinin ozonides against various strains of ... -
Antimicrobial activity and in vitro cytotoxicity of selected South African Helichrysum species
(Elsevier, 2011)The antimicrobial activity of 35 indigenous South African Helichrysum species was determined against six microorganisms. Seven of the 36 chloroform:methanol (1:1) extracts (leaf and stem extracts for all plants and an ... -
The antioxidant properties, cytotoxicity and monoamine oxidase inhibition abilities of the crude dichloromethane extract of Tarchonanthus camphoratus L. leaves
(Academic Journals, 2011)Tarchonanthus camphoratus (camphor bush) has been widely used for numerous medicinal purposes. The aim of the present study was to evaluate the antioxidant properties, cytotoxicity and monoamine oxidase inhibition activities ... -
Development of pyridyl thiosemicarbazones as highly potent agents for the treatment of malaria after oral administration
(Oxford Univ Press, 2019)Objectives Drug resistance exists to all current and investigational antimalarial drug classes. Consequently, we have set out to develop chemically and mechanistically discrete antimalarials. Here we report on the development ... -
In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract
(Wiley, 2008)The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR ... -
In vitro evaluation of the cytotoxic and apoptogenic properties of aloe whole leaf and gel materials
(Taylor & Francis, 2014)Aloe gel and whole-leaf materials have shown biological effects with potential therapeutic applications, and recently, their drug-absorption enhancement properties have been discovered. It is important to establish a ... -
In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species
(Elsevier, 2017)Ethnopharmacological relevance Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ... -
Poly (D,L-lactide-co-glycolide) nanoparticles: uptake by epithelial cells and cytotoxicity
(Budapest University of Technology, 2014)Nanoparticles as drug delivery systems offer benefits such as protection of the encapsulated drug against degradation, site-specific targeting and prolonged blood circulation times. The aim of this study was to investigate ... -
Synthesis and in vitro antileishmanial efficacy of benzyl analogues of nifuroxazide
(Wiley, 2020)Leishmaniasis is a vector‐borne parasitic disease that mostly affects populations in tropical and subtropical countries. There is currently no vaccine to protect against and only a handful of drugs are available to treat ... -
Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds
(Elsevier, 2012)Series of bisquinolines 4e15 and bispyrrolo[1,2a]quinoxalines 16e20 containing various polyamine linkers were synthesized. The aqueous solubility and distribution coefficient were experimentally determined. The compounds ...