Browsing Faculty of Health Sciences by Issue Date
Now showing items 1-20 of 2369
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Variable-temperature X-ray powder diffraction analysis of the crystal transformation of the pharmaceutically preferred polymorph C of mebendazole
(Elsevier, 2005)Mebendazole is a common benzimidazole anthelmintic that is water insoluble. It is reported to exist in three different polymorphic forms in the solid state, i.e. polymorph A, B and C. Form C is the pharmaceutically preferred ... -
Synthesis and transdermal properties of acetylsalicylic acid and selected esters
(Elsevier, 2006)The primary aim of this study was to determine the transdermal penetration of acetylsalicylic acid and some of its derivatives, to establish a correlation, if any, with selected physicochemical properties and to determine ... -
Dual inhibition of monoamine oxidase B and antagonism of the adenosine A2A receptor by (E,E)-8-(4phenylbytadien-1-yl) caffeine analogues
(Elsevier, 2008)The adenosine A2A receptor has emerged as an attractive target for the treatment of Parkinson’s disease (PD). Evidence suggests that antagonists of the A2A receptor (A2A antagonists) may be neuroprotective and may help to ... -
Structure-activity relationships in the inhibition of monoamine oxidase B by 1-methyl-3-phenylpyrroles
(Elsevier, 2008)1-Methyl-3-phenyl-3-pyrrolines are structural analogues of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and like MPTP are selective substrates of monoamine oxidase B (MAO-B). As part of an ongoing ... -
Deuterium isotope effects for the oxidation of 1-methyl-3phenyl-3pyrrolinyl analogues by monoamine oxidase B
(Elsevier, 2008)The parkinsonian inducing agent, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is a cyclic tertiary allylamine exhibiting good monoamine oxidase B (MAO-B) substrate properties. MAO-B catalyzes the ring α-carbon ... -
Stress and re-stress increases conditioned taste aversion learning in rats: possible frontal cortical and hippocampal muscarinic receptor involvement
(Elsevier, 2008)Symptoms of posttraumatic stress disorder are often precipitated by sensory cues in the form of visual, auditory, olfactory and gustatory “flashbacks” resulting in enhanced fear-memory consolidation and the characteristic ... -
Development of microporous drug-releasing films cast from artificial nanosized latexes of poly (styrebe-co-methyl methacrylate) or poly (styrene-co-ethyl methacylate)
(Elsevier, 2008)Two sets of copolymers comprising of styrene and either methyl or ethyl methacrylate as comonomer were conveniently synthesized by microemulsion copolymerization. The purified materials were characterized by GPC-MALLS and ... -
Intestinal drug absorption enhancers: synergistic effects of combinations
(Taylor & Francis, 2008)Although many absorption enhancers have been investigated, very few are used clinically. A need exists therefore for more effective absorption enhancers. The drug-absorption-enhancing effects of combinations of N-trimethyl ... -
Medicinal chemistry of polycyclic cage compounds in drug discovery research
(Springer, 2008)Saturated polycyclic hydrocarbon structures such as the monocyclic octane, bicylic norbornane and tricyclic adamantane have attracted the attention of several research groups since the 1930s. In the 1950s the synthesis of ... -
N, N-Bis (trifluoromethylquinoline-4-yl)diamino alkanes: synthesis and antimalarial activity
(Bentham Science, 2008)A series of N,N-bis(trifluoromethylquinolin-4-yl)- and N,N-bis[2,8-bis(trifluoromethyl)quinolin-4-yl] diamino alkane and piperazine derivatives were synthesised by employing a simple and rapid displacement reaction of the ... -
Synthesis, complete 1H and 13C NMR assignment and crystal structure of novel epoxide derivatives of cytochalasin B
(University of Stellenbosch, 2008)Five novel epoxide derivatives of cytochalasin B were synthesized. Reaction of cytochalasin B with t-BHP and BuLi led to selective epoxidation of the C-21/22 double bond to give a single monoepoxide, while reaction with ... -
Transport of aspalathin, a rooibos tea flavonoid, across the skin and intestinal epithelium
(Wiley, 2008)Since Rooibos tea contains high levels of flavonoid antioxidants with potential health benefits when taken orally or applied topically, the quantity of the antioxidants crossing the physiological barriers is of scientific, ... -
In vitro antioxidant, antimutagenic and genoprotective activity of Rosa roxburghii fruit extract
(Wiley, 2008)The antioxidant properties of the fruit of the Rosa roxburghii (RR) plant have been associated with several putative health promoting effects. The possible cytotoxic, mutagenic/antimutagenic and genotoxic effects of RR ... -
Solvent inclusion by the anti-HIV drug nevirapine: X-ray structures and thermal decomposition of representative solvates
(ACS, 2008)Five crystalline solvates of the anti-HIV drug Nevirapine (N), with compositions N·(ethyl acetate)0.5 (1), N·(dichloromethane)0.5 (2), N·(toluene)0.5 (3), N·(water)0.5 (4), and N·(1,4-dioxane)1.5 (5), were isolated and ... -
Fluorescent polycyclic ligands for nitric oxide synthase (NOS) inhibition
(Elsevier, 2008)In recent years polycyclic compounds have been shown to exhibit pharmacological profiles of importance in the symptomatic and proposed curative treatment of neurodegenerative diseases (e.g., Parkinson’s and Alzheimer’s ... -
Coping with urbanization: a cardiometabolic risk? The THUSA study
(Elsevier, 2008)An assessment of specific coping styles in rural-urban Africans is done to evaluate its contribution as cardiometabolic risk factor. In total, 608 apparently healthy Africans were included in a cross-sectional comparative ... -
Genetic polymorphisms of beta(2)- and beta(3)- adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women
(Thieme, 2008)Background: Genetic variation in the β2 (ADRB2) and β3 (ADRB3) adrenergic receptor genes are associated with obesity and insulin resistance. To further elucidate the role of these genes in the pathophysiology of obesity ... -
Hyperuricaemia is an independent factor for the metabolic syndrome in a sub-Saharan African population: a factor analysis
(Elsevier, 2008)Objective To assess the risk factor pattern of the metabolic syndrome and its association with insulin resistance and hyperuricaemia in a sub-Saharan African population with different levels of urbanisation. Methods Four ... -
Investigating the potential neuroprotective effects of statins on DNA damage in mouse striatium
(Elsevier, 2008)We investigated the protective effect of pravastatin, simvastatin and atorvastatin on striatal DNA damage as a potential method to conserve and protect the nigrostriatal neurons. C57Bl/J6 mice were treated with combinations ... -
Effect of chronic N-acetyl cystine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum
(Springer, 2008)Antioxidants have possible therapeutic value in neurodegenerative disorders, although they may have pro-oxidant effects under certain conditions. Glutathione (GSH) is a key free radical scavenger. N-acetylcysteine (NAC) ...