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Systemic and organ specific metabolic variation in metallothionein knockout mice challenged with swimming exercise
(Springer, 2013)
Metallothioneins (MTs) are ubiquitous, multifunctional
proteins with key roles in metal homeostasis and
redox regulation. Their involvement in cellular energy
metabolism is evident from the observation that metallothi ...
A metabolomics approach exploring the function of the ESX-3 type VII secretion system of M. smegmatis
(Springer, 2013)
The genome of Mycobacterium, including
Mycobacterium tuberculosis, contains five copies of a
cluster of genes encoding a novel type VII secretion system,
named the ESX gene cluster region. This ESX-3 gene
cluster is ...
Disclosure of a putative biosignature for respiratory chain disorders through a metabolomics approach
(Springer, 2013)
The diagnosis of respiratory chain deficiencies
(RCDs) is complicated and the need for a diagnostic biomarker
or biosignature has been widely expressed. In this
study, the metabolic profile of a selected group of 29 ...
New sputum metabolite markers implicating adaptations of the host to Mycobacterium tuberculosis, and vice versa
(Elsevier, 2013)
In this study, a metabolomics research approach was used to identify new tuberculosis (TB) markers from
sputum, in an attempt to better characterise the disease as well as the metabolic response of the host to
Mycobacterium ...