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Uncovering the metabolic response of abalone (Haliotis midae) to environmental hypoxia through metabolomics
(Springer, 2018)
Introduction
Oxygen is essential for metabolic processes and in the absence thereof alternative metabolic pathways are required for energy production, as seen in marine invertebrates like abalone. Even though hypoxia has ...
The cross-tissue metabolic response of abalone (Haliotis midae) to functional hypoxia
(The Company of Biologists, 2018)
Functional hypoxia is a stress condition caused by the abalone itself as
a result of increased muscle activity, which generally necessitates the
employment of anaerobic metabolism if the activity is sustained for
prolonged ...
TB or not TB? Improving the understanding and diagnosis of tuberculosis through metabolomics
(Future Medicine, 2016)
“
...metabolomics has resulted in an exponential increase in the
number of newly identified tuberculosis biomarkers, which has not
only shed light on previously unknown disease mechanisms, but could
potentially ...
Metabolomics and personalized medicine
(Elsevier, 2016)
Current clinical practice strongly relies on the prognosis, diagnosis, and treatment of diseases using methods determined and averaged for the specific diseased cohort/population. Although this approach complies positively ...
Fatty acid metabolome extraction from mycobacterial cells for GC-MS metabolomics analysis
(Humana, 2019)
Metabolomics is becoming an increasingly popular research tool for identifying new biomarkers, which can, among other applications, be applied to elucidate various microbial growth and virulence mechanisms. Since the lipid ...
The application of metabolomics toward pulmonary tuberculosis research
(Elsevier, 2019)
In the quest to identify novel biomarkers for pulmonary tuberculosis (TB), high-throughput systems biology approaches such as metabolomics has become increasingly widespread. Such biomarkers have not only successfully been ...
Metabolomics describes previously unknown toxicity mechanisms of isoniazid and rifampicin
(Elsevier, 2020)
Isoniazid and rifampicin are well-known anti-mycobacterial agents and are widely used to treat pulmonary tuberculosis (TB) as part of the combined therapy approach, recommended by the World Health Organization. The ingestion ...
Metabolic characterization of tuberculous meningitis in a South African paediatric population using 1H NMR metabolomics
(Elsevier, 2020)
Objective
To better characterize the cerebrospinal fluid (CSF) metabolic profile of tuberculous meningitis (TBM) cases using a South African paediatric cohort.
Methods
1H NMR metabolomics was used to analyse the CSF ...
Metabolomics biomarkers for tuberculosis diagnostics: current status and future objectives
(Future Medicine, 2017)
Numerous studies have contributed to our current understanding of the complex biology of pulmonary tuberculosis and subsequently provided solutions to its control or eradication. Metabolomics, a newcomer to the Omics ...
A metabolomics investigation of the function of the ESX-1 gene cluster in mycobacteria
(Elsevier, 2016)
The ESX-1 gene cluster, encoding the Type-VII secretion (T7S) system and its virulence associated proteins, ESAT-6 and CFP-10, is thought to be responsible for the transport of extracellular proteins across the hydrophobic ...