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The design and evaluation of an l-dopa-lazabemide prodrug for the treatment of Parkinson’s disease
(MDPI, 2017)
l-Dopa, the metabolic precursor of dopamine, is the treatment of choice for the symptomatic relief of the advanced stages of Parkinson’s disease. The oral bioavailability of l-dopa, however, is only about 10% to 30%, and ...
2-Acetylphenol analogs as potent reversible monoamine oxidase inhibitors
(Dove Press, 2015)
Based on a previous report that substituted 2-acetylphenols may be promising leads for the design of novel monoamine oxidase (MAO) inhibitors, a series of C5-substituted 2-acetylphenol analogs (15) and related compounds ...
3-Coumaranone derivatives as inhibitors of monoamine oxidase
(Dove Press, 2015)
The present study examines the monoamine oxidase (MAO) inhibitory properties of a series of 20 3-coumaranone [benzofuran-3(2H)-one] derivatives. The 3-coumaranone derivatives are structurally related to series of α-tetralone ...
Mirror training augments the cross-education of strength and affects inhibitory paths
(American College of Sports Medicine, 2016)
Purpose: Unilateral
strength training strengthens not only the muscles on the trained side but also the homologous muscles on the untrained side; however,
the magnitude of this interlimb cross-education is modest. We ...
Inhibition of c-steel corrosion by green tea extract in hydrochloric solution
(ESG, 2017)
Inhibition ability of green tea extract (GTE) on the C38 steel (CS) in 1.0 M HCl was evaluated using different methods such as: weight loss, electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization ...
Monoamine oxidase inhibition properties of 2,1‑benzisoxazole derivatives
(Springer, 2023)
onoamine oxidase (MAO) are favoenzymes that metabolize neurotransmitter, dietary and xenobiotic amines to their corre sponding aldehydes with the production of hydrogen peroxide. Two isoforms, MAO-A and MAO-B, are expressed ...
The inhibition of monoamine oxidase by esomeprazole
(Thieme, 2013)
Virtual screening of a library of drugs has suggested that esomeprazole, the S-enantiomer of omeprazole, may possess binding affinities for the active sites of the monoamine oxidase (MAO) A and B enzymes. Based on this ...