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Inhibition of monoamine oxidase by phthalide analogues
(Elsevier, 2013)
Based on recent reports that the small molecules, isatin and phthalimide, are suitable scaffolds for the
design of high potency monoamine oxidase (MAO) inhibitors, the present study examines the MAO inhibitory
properties ...
Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives
(Elsevier, 2013)
In the present study, a series of 3,4-dihydro-2(1H)-quinolinone derivatives were synthesized and evaluated
as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 3,4-dihydro-2(1H)-
quinolinone derivatives ...
Inhibition of monoamine oxidase by selected phenylalkylcaffeine analogues
(Wiley, 2014)
Objectives Caffeine represents a useful scaffold for the design of monoamine
oxidase (MAO) type B inhibitors. Specifically, substitution on the C8 position
yields structures which are high-potency MAO-B inhibitors. To ...
Selected chromone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2012)
A previous study has shown that a series of C6-benzyloxy substituted chromones exhibit high binding affinities for human monoamine oxidase (MAO) B. In an attempt to discover additional chromones with potent and selective ...
Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives
(Elsevier, 2012)
A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ...
Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues
(Elsevier, 2012)
In a previous study we have investigated the monoamine oxidase (MAO) inhibitory properties of a series of 8-sulfanylcaffeine analogues. Among the compounds studied, 8-[(phenylethyl)sulfanyl]caffeine (IC50 = 0.223 lM) was ...
Inhibition of monoamine oxidase by selected C6-substituted chromone derivatives
(Elsevier, 2012)
Chromone has been reported to be a useful scaffold for the design of monoamine oxidase (MAO) inhibitors. In an attempt to discover highly potent MAO inhibitors and to contribute to the known structureeactivity relationships ...
Monoamine oxidase inhibition by C4-substituted phthalonitriles
(Elsevier, 2012)
It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms ...
Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues
(Elsevier, 2011)
Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform ...
Inhibition of monoamine oxidase by C5-substituted phthalimide analogues
(Elsevier, 2011)
Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors
of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced binding ...