Browsing Research Output by Subject "Apoptosis"
Now showing items 1-10 of 13
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Anticancer activity, apoptosis and a structure-activity analysis of a series of 1,4-naphthoquinone-2,3-bis-sulfides
(Springer, 2020)We have previously reported on the synthesis of 1,4-naphthoquinone-sulfides and in this investigation we report on their anticancer activity against 6 human cancer cell lines to evaluate their cytostatic effects. The ... -
Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells
(BioMed Central, 2016)BACKGROUND: Cervical cancer remains a global health related issue among females of Sub-Saharan Africa, with over half a million new cases reported each year. Different therapeutic regimens have been suggested in various ... -
Characterization of the cell-free DNA released by cultured cancer cells
(Elsevier, 2016)The most prominent factor that delays the translation of cell-free DNA (cfDNA) analyses to clinical practice is the lack of knowledge regarding its origin and composition. The elucidation of the former is complicated by ... -
Circulating DNA: its origin and fluctuation
(Wiley, 2008)Circulating DNA is present in the blood of all individuals, but it has been found that cancer patients and patients with a variety of other conditions have increased amounts of these circulating DNA fragments in their ... -
Curcumin rescues a PINK1 knock down SH-SY5Y cellular model of Parkinson’s disease from mitochondrial dysfunction and cell death
(Springer, 2017)Parkinson’s disease (PD) is a neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra. Mutations in the PINK1 gene result in an autosomal recessive form of early-onset PD. ... -
An enquiry concerning the characteristics of cell-free DNA released by cultured cancer cells
(Springer, 2016)Non-invasive screening that utilizes cell-free DNA (cfDNA) offers remarkable potential as a method for the early detection of genetic disorders and a wide variety of cancers. Unfortunately, one of the most prominent elements ... -
Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro
(Elsevier, 2017)In the Krebs cycle, succinate is oxidized to fumarate by succinate dehydrogenase (SDH), followed by the conversion of fumarate to malate by fumarate hydratase (FH). In cells with defective SDH and FH, the Krebs cycle is ... -
In vitro evaluation of the cytotoxic and apoptogenic properties of aloe whole leaf and gel materials
(Taylor & Francis, 2014)Aloe gel and whole-leaf materials have shown biological effects with potential therapeutic applications, and recently, their drug-absorption enhancement properties have been discovered. It is important to establish a ... -
Origin, translocation and destination of extracellular occurring DNA: a new paradigm in genetic behaviour
(Elsevier, 2011)The diagnostic value of extracellular occurring DNA (eoDNA) is limited by our lack of understanding its biological function. eoDNA exists in a number of forms, namely vesicle bound DNA (apoptotic bodies, micro particles, ... -
Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents
(Elsevier, 2014)The aim of this study was to design drug-like molecules with multiple neuroprotective mechanisms which would ultimately inhibit N-methyl-D-aspartate (NMDA) receptors, block L-type voltage gated calcium channels (VGCC) ...