Browsing Research Output by Subject "Antimalarial activity"
Now showing items 1-3 of 3
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Methylene homologues of artemisone: an unexpected structure-activity relationship and a possible implication for the design of C10-substituted artemisinins
(Wiley, 2016)We sought to establish if methylene homologues of artemisone are biologically more active and more stable than artemisone. The analogy is drawn with the conversion of natural O- and N-glycosides into more stable C-glycosides ... -
Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities
(Elsevier, 2016)As part of a programme aimed at identifying rational new triple drug combinations for treatment of malaria, tuberculosis and toxoplasmosis, we have selected quinolones as one component, given that selected examples exhibit ... -
Synthesis, cytotoxicity and antimalarial activity of ferrocenyl amides of 4-aminoquinolines
(Thieme, 2010)Series of 4-aminoquinolines bearing an amino side chain linked to the ferrocene moiety through an amide bond were synthesized and evaluated for their antimalarial activity against both chloro-quine-sensitive (D10, CQ-S) ...