Browsing Research Output by Subject "Amorphous"
Now showing items 1-9 of 9
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Amorphous azithromycin with improved aqueous solubility and intestinal membrane permeability
(Taylor & Francis, 2015)Azithromycin (AZM) is a poorly soluble macrolide antibacterial agent. Its low solubility is considered as the major contributing factor to its relatively low oral bioavailability. The aim of this study was to improve the ... -
Amorphous sulfadoxine: a physical stability and crystallization kinetics study
(Springer Nature, 2016)Poor aqueous solubility of drugs and the improvement thereof has always been a challenge for the pharmaceutical industry.With this, one of the focuses of the pharmaceutical research scientist involves investigating ... -
Different amorphous solid-state forms of roxithromycin: a thermodynamic and morphological study
(Elsevier, 2016)The striking impact that different preparation methods have on the characteristics of amorphous solidstate forms has attracted considerable attention during the last two decades. The pursuit of more extensive knowledge ... -
The effect of temperature and moisture on the amorphous-to-crystalline transformation of stavudine
(Elsevier, 2009)Stavudine is a nucleoside reverse transcriptase inhibitor active against HIV, and is known to exist in two polymorphic forms designated as forms I and II, and a hydrate form III. An amorphous solid of stavudine was ... -
Physicochemical properties of amorphous roxithromycin prepared by quench cooling of the melt or desolvation of a chloroform solvate
(Springer, 2012)Roxithromycin is a poorly soluble antibacterial drug. The aim of this study was to prepare and characterize an amorphous form of roxithromycin. The amorphous form was prepared by desolvation of its chloroform solvate, and ... -
Preparation and transformation of true nifedipine polymorphs: investigated with differential scanning calorimetry and X-Ray diffraction pattern fitting methods
(Elsevier, 2011)The amorphous → metastable and metastable → stable crystalline phase transitions of nifedipine and their relationship with polymorph composition during storage at controlled temperature/humidity conditions were investigated. ... -
Solution-mediated phase transformation of different roxithromycin solid-state forms: implications on dissolution and solubility
(Elsevier, 2013)The objective of this study was to describe the solid-state forms in which roxithromycin may exist and the significant influence of solution-mediated phase transformation on the dissolution and solubility behavior of ... -
The stabilization of amorphous zopiclone in an amorphous solid dispersion
(Springer, 2015)Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and characterize an amorphous form of zopiclone as well as the characterization and performance of a stable amorphous solid ... -
Topical delivery of roxithromycin solid-state forms entrapped in vesicles
(Elsevier, 2017)Recently, considerable interest developed in using newer/improved antibiotics for the treatment of Acne vulgaris. During this study, different roxithromycin solid-state forms (i.e. crystalline and amorphous) were encapsulated ...