Now showing items 1-10 of 11

    • 3-Coumaranone derivatives as inhibitors of monoamine oxidase 

      Van Dyk, Adriaan S.; Petzer, Jacobus P.; Petzer, Anél; Legoabe, Lesetja J. (Dove Press, 2015)
      The present study examines the monoamine oxidase (MAO) inhibitory properties of a series of 20 3-coumaranone [benzofuran-3(2H)-one] derivatives. The 3-coumaranone derivatives are structurally related to series of α-tetralone ...
    • Evaluation of natural and synthetic 1,4-naphthoquinones as inhibitors of monoamine oxidase 

      Mostert, Samantha; Petzer, Anél; Petzer, Jacobus P. (Wiley, 2016)
      Previous reports have documented that 1,4-naphtho- quinones act as inhibitors of the monoamine oxidase (MAO) enzymes. In particular, fractionation of the extracts of cured tobacco leafs has led to the charac- terization ...
    • Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives 

      Okaecwe, Thokozile; Swanepoel, Abraham J.; Petzer, Anél; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2012)
      A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ...
    • The inhibition of monoamine oxidase by esomeprazole 

      Petzer, A.; Pienaar, A.; Petzer, J.P. (Thieme, 2013)
      Virtual screening of a library of drugs has suggested that esomeprazole, the S-enantiomer of omeprazole, may possess binding affinities for the active sites of the monoamine oxidase (MAO) A and B enzymes. Based on this ...
    • Inhibition of monoamine oxidase by selected phenylalkylcaffeine analogues 

      Petzer, Anél; Grobler, Paul; Bergh, Jacobus J.; Petzer, Jacobus P. (Wiley, 2014)
      Objectives Caffeine represents a useful scaffold for the design of monoamine oxidase (MAO) type B inhibitors. Specifically, substitution on the C8 position yields structures which are high-potency MAO-B inhibitors. To ...
    • The interactions of caffeine with monoamine oxidase 

      Petzer, Anél; Pienaar, Anke; Petzer, Jacobus P. (Elsevier, 2013)
      Aims: Caffeine has been used as a scaffold for the design of inhibitors of monoamine oxidase (MAO) A and B. Substitution at the C8 position with a variety of moieties yields structures with high MAO inhibition ...
    • Monoamine oxidase inhibitory activities of heterocyclic chalcones 

      Minders, Corné; Petzer, Jacobus P.; Petzer, Anél; Lourens, Anna C.U. (Elsevier, 2015)
      Studies have shown that natural and synthetic chalcones (1,3-diphenyl-2-propen-1-ones) possess monoamine oxidase (MAO) inhibition activities. Of particular importance to the present study is a report that a series of ...
    • Optimised dynamic control philosophy for improved performance of mine cooling systems 

      Crawford, J.A.; Joubert, H.P.R.; Mathews, M.J.; Kleingeld, M. (Elsevier, 2019)
      Mine workers require substantial cooling and ventilation to work in a safe and habitable environment. Deep level mine cooling systems were identified as significant energy-intensive consumers to supply such cooling. Mine ...
    • Selected furanochalcones as inhibitors of monoamine oxidase 

      Robinson, Sarel J.; Petzer, Jacobus P.; Petzer, Anél; Bergh, Jacobus J.; Lourens, Anna C.U. (Elsevier, 2013)
      The validity of the chalcone scaffold for the design of inhibitors of monoamine oxidase has previously been illustrated. In a systematic attempt to investigate the effect of heterocyclic substitution on the monoamine ...
    • The synthesis and evaluation of C7-substituted α-tetralone derivatives as inhibitors of monoamine oxidase 

      Legoabe, Lesetja J.; Petzer, Anél; Petzer, Jacobus P. (Wiley, 2015)
      Based on a previous report that α-tetralone (3,4-dihydro-2H-naphthalen-1-one) is a promising scaffold for the design of highly potent inhibitors of the enzyme, monoamine oxidase, the present study investigates the monoamine ...