Browsing Research Output by Author "10055037 - Reinecke, Carolus Johannes"
Now showing items 1-20 of 29
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1H NMR spectral identification of medication in cerebrospinal fluid of pediatric meningitis
Mason, Shayne; Reinecke, Carolus J.; Solomons, Regan; Wevers, Ron; Engelke, Udo F.H. (Elsevier, 2017)Exploratory metabolomics studies of cerebrospinal fluid (CSF), using proton nuclear magnetic resonance (1H NMR) spectroscopy, hold major potential application in neurodiagnostics. Such studies, however, rely upon established ... -
The 1H-NMR-based metabolite profile of acute alcohol consumption: a metabolomics intervention study
Irwin, Cindy; Van Reenen, Mari; Mason, Shayne; Mienie, Lodewyk J.; Westerhuis, Johan A.; Reinecke, Carolus J. (PLoS, 2018)Metabolomics studies of disease conditions related to chronic alcohol consumption provide compelling evidence of several perturbed metabolic pathways underlying the pathophysiology of alcoholism. The objective of the present ... -
3-Methylglutaconic aciduria: lessons from 50 genes and 977 patients
Wortmann, Saskia B.; Reinecke, Carolus J.; Van der Westhuizen, Francois H.; Kluijtmans, Leo A. J.; Rodenburg, Richard J. (Springer, 2013)Elevated urinary excretion of 3-methylglutaconic acid is considered rare in patients suspected of a metabolic disorder. In 3-methylglutaconyl-CoA hydratase deficiency (mutations in AUH), it derives from leucine degradation. ... -
Attitudes and perceptions regarding metabolomics research on HIV and AIDS: towards a dynamic model relating basic beliefs, technology and behaviour
Jochemsen, Henk; Reinecke, Carolus; Zaaiman, Johan; Nonyane, Honey (AOSIS, 2014)The human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) pandemic are hitting hard in Africa, not the least in South Africa. In addition to preventative measures, better ways of treatment and ... -
Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge
Erasmus, Elardus; Van Reenen, Mari; Vorster, B. Chris; Reinecke, Carolus J.; Steffens, Francois E. (Public Library of Science, 2019)Chronic fatigue, in its various manifestations, frequently co-occur with pain, sleep disturbances and depression and is a non-communicable condition which is rapidly becoming endemic worldwide. However, it is handicapped ... -
Cerebrospinal fluid amino acid profiling of pediatric cases with tuberculous meningitis
Mason, Shayne; Reinecke, Carolus J.; Solomons, Regan (Frontiers Media, 2017)Background: In Africa, tuberculosis is generally regarded as persisting as one of the most devastating infectious diseases. The pediatric population is particularly vulnerable, with infection of the brain in the form of ... -
Cerebrospinal fluid in tuberculous meningitis exhibits only the L-enantiomer of lactic acid
Mason, Shayne; Reinecke, Carolus J.; Kulik, Willem; Van Cruchten, Arno; Solomons, Regan (BioMed Central, 2016)Background: The defining feature of the cerebrospinal fluid (CSF) collected from infants and children with tuberculous meningitis (TBM), derived from an earlier untargeted nuclear magnetic resonance (NMR) metabolomics ... -
Clinical variability of isovaleric acidemia in a genetically homogeneous population
Dercksen, M.; Mienie, L.J.; Reinecke, C.J.; Duran, M.; Ijlst, L.; Wanders, R.J.A. (Springer, 2012)Isovaleric acidemia (IVA) is one of the most common organic acidemias found in South Africa. Since 1983, a significant number of IVA cases have been identified in approximately 20,000 Caucasian patients screened for metabolic ... -
Concurrent class analysis identifies discriminatory variables from metabolomics data on isovaleric acidemia
Koekemoer, Gerhard; Dercksen, Marli; Allison, James; Santana, Leonard; Reinecke, Carolus J. (Springer, 2012)Metabolomics data are typically complex and high dimensional. Multivariate dimension-reducing techniques have thus been developed for analysing metabolomics data to disclose underlying relationships, with principal component ... -
Contribution towards a metabolite profile of the detoxification of benzoic acid through glycine conjugation: an intervention study
Irwin, Cindy; Van Reenen, Mari; Mason, Shayne; Mienie, Lodewyk J.; Reinecke, Carolus J.; Westerhuis, Johan A. (PLoS, 2016)Benzoic acid is widely used as a preservative in food products and is detoxified in humans through glycine conjugation. Different viewpoints prevail on the physiological significance of the glycine conjugation reaction ... -
A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls
Malatji, Bontle G.; Mason, Shayne; Van Reenen, Mari; Reinecke, Carolus J.; Meyer, Helgard (BioMed Central, 2017)Background: Fibromyalgia syndrome (FMS) is a chronic pain syndrome. A plausible pathogenesis of the disease is uncertain and the pursuit of measurable biomarkers for objective identification of affected individuals is a ... -
Disclosure of a putative biosignature for respiratory chain disorders through a metabolomics approach
Smuts, Izelle; Van der Westhuizen, Francois H.; Louw, Roan; Mienie, Lodewyk J.; Mason, Shayne; Koekemoer, Gerhard; Reinecke, Carolus J. (Springer, 2013)The diagnosis of respiratory chain deficiencies (RCDs) is complicated and the need for a diagnostic biomarker or biosignature has been widely expressed. In this study, the metabolic profile of a selected group of 29 ... -
Fetal metabolic stress disrupts immune homeostasis and induces proinflammatory responses in human immunodeficiency virus type 1- and combination antiretroviral therapy-exposed infants
Schoeman, Johannes C.; Moutloatse, Gontse P.; Reinecke, Carools J.; Harms, Amy C.; Vreeken, Rob J. (Oxford Univ Press, 2017)Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological ... -
The GC-MS metabolomics signature in patients with fibromyalgia syndrome directs to dysbiosis as an aspect contributing factor of FMS pathophysiology
Malatji, Bontle G.; Mason, Shayne; Mienie, Lodewyk J.; Van Reenen, Mari; Reinecke, Carolus J. (Springer, 2019)Introduction Fibromyalgia syndrome (FMS) is a chronic pain syndrome. Previous analyses of untargeted metabolomics data indicated altered metabolic profile in FMS patients. Objectives We report a semi-targeted explorative ... -
GC-MS-based urinary organic acid profiling reveals multiple dysregulated metabolic pathways following experimental acute alcohol consumption
Irwin, Cindy; Mienie, Lodewyk J.; Mason, Shayne; Van Reenen, Mari; Reinecke, Carolus J. (Nature, 2018)Metabolomics studies of diseases associated with chronic alcohol consumption provide compelling evidence of several perturbed metabolic pathways. Moreover, the holistic approach of such studies gives insights into the ... -
A hypothetical astrocyte-microglia lactate shuttle derived from a 1H NMR metabolomics analysis of cerebrospinal fluid from a cohort of South African children with tuberculous meningitis
Mason, Shayne; Mienie, Lodewyk J.; Reinecke, Carolus J.; Van Furth, A. Marceline; Engelke, Udo F.H. (Springer, 2015)Tuberculosis meningitis (TBM) is the most severe form of extra-pulmonary tuberculosis and is particularly intense in small children; there is no universally accepted algorithm for the diagnosis and substantiation of TB ... -
A laboratory approach for characterizing chronic fatigue: what does metabolomics tell us?
Erasmus, Elardus; Mason, Shayne; Van Reenen, Mari; Vorster, B. Chris; Reinecke, Carolus J. (Springer, 2019)Introduction Manifestations of fatigue range from chronic fatigue up to a severe syndrome and myalgic encephalomyelitis. Fatigue grossly affects the functional status and quality of life of affected individuals, prompting ... -
Metabolic risks at birth of neonates exposed in utero to HIV-antiretroviral therapy relative to unexposed neonates: an NMR metabolomics study of cord blood
Moutloatse, Gontse P.; Van Reenen, Mari; Mason, Shayne; Reinecke, Carools J.; Bunders, Madeleine J. (Springer, 2016)Introduction Antiretroviral therapy (ART) for HIV-infected pregnant women is highly effective in preventing mother-to-child transmission (PMTCT) of the virus, but deleterious metabolic and mitochondrial observations in ... -
Metabolic risks of neonates at birth following in utero exposure to HIV-ART: the amino acid profile of cord blood
Moutloatse, Gontse P.; Lindeque, Zander; Van Reenen, Mari; Reinecke, Carolus J.; Schoeman, Johannes C. (Springer, 2017)Introduction Untargeted metabolomics of cord blood indicated that antiretroviral therapy to HIV-infected mothers (HIV-ART) did not compromise the exposed neonates with regard to the stress of neonatal hypoglycaemia at ... -
Metabolomics of urinary organic acids in respiratory chain deficiencies in children
Reinecke, Carolus J.; Koekemoer, Gerhard; Van der Westhuizen, Francois H.; Louw, Roan; Lindeque, Jeremie Z.; Mienie, Lodewyk J.; Smuts, Izelle (Springer, 2012)Metabolomic analysis of the urinary organic acids from 39 selected children with defined respiratory chain deficiencies (RCDs) was performed using untargeted gas chromatography–mass spectrometry, revealing the presence ...