dc.contributor.author | Schutte, A.E. | |
dc.contributor.author | Schutte, R. | |
dc.contributor.author | Smith, W. | |
dc.contributor.author | Huisman, H.W. | |
dc.contributor.author | Mels, C.M.C. | |
dc.contributor.author | Malan, L. | |
dc.contributor.author | Fourie, C.M.T. | |
dc.contributor.author | Malan, N.T. | |
dc.contributor.author | Van Rooyen, J.M. | |
dc.contributor.author | Kruger, R. | |
dc.date.accessioned | 2016-06-06T07:29:37Z | |
dc.date.available | 2016-06-06T07:29:37Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Schutte, A.E. et al. 2014. Compromised bioavailable IGF-1 of black men relates favourably to ambulatory blood pressure: the SABPA study. Atherosclerosis, 233(1):139-144. [http://www.elsevier.com/locate/atherosclerosis] | en_US |
dc.identifier.issn | 0021-9150 | |
dc.identifier.issn | 1879-1484 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/17609 | |
dc.identifier.uri | http://dx.doi.org/10.1016/j.atherosclerosis.2013.12.025 | |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/24529134/ | |
dc.identifier.uri | https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.998.5588&rep=rep1&type=pdf | |
dc.description.abstract | Objectives
Insulin-like growth factor-1 (IGF-1) has potent endothelial-protective, anti-platelet and anti-thrombotic activities, and also exerts mitogenic and proliferatory actions on vascular smooth muscle cells. Conflicting reports exist regarding the role of IGF-1 in vascular protection and atherogenesis. We therefore investigated the relationships of ambulatory blood pressure (BP) and carotid intima-media thickness (cIMT) with a range of components of the IGF-1 axis in a bi-ethnic population.
Methods
We included black (N = 86) and white (N = 101) men and measured growth hormone, total IGF-1, insulin-like growth factor binding protein-3 (IGFBP-3), and pregnancy-associated plasma protein-A (PAPP-A) levels.
Results
Ambulatory BP was almost 10 mmHg higher in black men (137/88 mmHg versus 128/80 mmHg; both p < 0.001), accompanied by an adverse profile of the IGF-axis for all measured components (all p < 0.01), including reduced bioavailable IGF-1 (IGF-1/IGFBP-3; p = 0.006) and tissue IGF-1 accessibility index as represented by IGF-1.PAPP-A/IGFBP-3 (p < 0.001). Single, partial and multiple regression analyses confirmed an independent inverse association between ambulatory systolic BP and bioavailable IGF-1 in black men (R2 = 0.24; β = −0.22; p = 0.035). cIMT was similar in the ethnic groups (p = 0.34), and was negatively associated with bioavailable IGF-1 in white men (R2 = 0.42; β = −0.17; p = 0.039) prior to adjustment for γ-glutamyl transferase (R2 = 0.45; β = −0.10; p = 0.25).
Conclusion
Ambulatory systolic BP is inversely related to bioavailable IGF-1 in black men who displayed low IGF-1 concentrations. An inverse relation was found between cIMT and IGF-1 in white men, which disappeared after correction for γ-glutamyl transferase – opposing reports of a detrimental role of IGF-1 in the early stages of atherogenesis. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | insulin-like growth factor-1 | en_US |
dc.subject | insulin-like growth factor binding protein-3 | en_US |
dc.subject | growth hormone | en_US |
dc.subject | pregnancy-associated plasma protein-A | en_US |
dc.subject | African | en_US |
dc.subject | black | en_US |
dc.subject | atherosclerosis | en_US |
dc.subject | ambulatory blood pressure | en_US |
dc.title | Compromised bioavailable IGF-1 of black men relates favourably to ambulatory blood pressure: the SABPA study | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 10922180 - Schutte, Aletta Elisabeth | |
dc.contributor.researchID | 12201405 - Schutte, Rudolph | |
dc.contributor.researchID | 10062718 - Huisman, Hugo Willem | |
dc.contributor.researchID | 12076341 - Mels, Catharina Martha Cornelia | |
dc.contributor.researchID | 10060871 - Malan, Leoné | |
dc.contributor.researchID | 10062491 - Fourie, Catharina Maria Theresia | |
dc.contributor.researchID | 10056173 - Malan, Nicolaas Theodor | |
dc.contributor.researchID | 10059539 - Van Rooyen, Johannes Marthinus | |