Browsing by Author "10056173 - Malan, Nicolaas Theodor"
Now showing items 1-20 of 93
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8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: the SABPA study
Mels, C.M.C.; Schutte, A.E.; Schutte, R.; Pretorius, P.J.; Smith, W.; Huisman, H.W.; Van der Westhuizen, F.H.; Fourie, C.M.T.; Van Rooyen, J.M.; Kruger, R.; Louw, R.; Malan, N.T.; Malan, L. (Taylor & Francis, 2014)Various studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG). The aim of this study ... -
Acute cardiometabolic responses facilitating a state of chronic hyperglycemia and renal impairment: the SABPA study
Joosten, Liezl (Wolters Kluwer, 2014)"Background: Augmented α-adrenergic response patterns are associated with vascular risk in Africans. The aims of this study were 1) to assess ethnic differences between glucose and cardiovascular responses during acute ... -
Adipokines and cardiometabolic function: how are they interlinked?
Schutte, Aletta Elisabeth; Huisman, Hugo Willem; Schutte, Rudolph; Van Rooyen, Johannes Marthinus; Malan, Leoné; Fourie, Catharina Maria Theresia; Malan, Nicolaas Theodor (Elsevier, 2010)Objective Adipokines contribute directly to the coexistence of insulin resistance and endothelial dysfunction. Most studies focus on a single adipokine. We therefore investigated the independent relationships of leptin, ... -
Ambulatory blood pressure monitoring and morning surge in blood pressure in adult black and white South Africans
Lambert, Gavin W.; Malan, Nicolaas T.; Malan, Leoné; Head, Geoffrey A.; Chen, Won Sun (Wiley, 2020)We examined whether there were differences in the circadian variation in blood pressure and the morning surge in blood pressure between black and white Africans. Clinic and ambulatory blood pressure data obtained from the ... -
Arterial stiffness profiles: investigating various sections of the arterial tree of African and caucasian people
Huisman, Hugo Willem; Malan, Nicolaas Theodor; Schutte, Aletta Elisabeth; Schutte, Rudolph; Van Rooyen, Johannes Marthinus; Malan, Leoné; Reimann, Manja (Informa healthcare, 2011)In Africans, arterial stiffness progression seems more pronounced compared to Caucasians. We compared the arterial stiffness profiles of different age groups and focused on muscular arteries and two more central arterial ... -
Arterial stiffness, ambulatory blood pressure and low-grade albuminuria in non-diabetic African and caucasian men: the SABPA study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Glyn, Matthew C.P.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Fourie, Carla M.T.; Malan, Leoné (Nature Publishing Group, 2011)Recent evidence suggests that low-grade urinary albumin excretion is a marker of early general attenuation of vascular function, but studies are limited to Caucasian population groups. We compared low-grade urinary albumin ... -
The association of 25(OH)D with blood pressure, pulse pressure and carotid–radial pulse wave velocity in African women
Kruger, Iolanthé M.; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Schutte, Rudolph; Malan, Leoné; Malan, Nicolaas T.; Fourie, Carla M.T.; Kruger, Annamarie (Public Library of Science, 2013)High susceptibility of the African population to develop cardiovascular disease obliges us to investigate possible contributing risk factors. Our aim was to determine whether low 25(OH)D status is associated with increased ... -
The Association of Red Blood Cell Counts with Endothelin-1 in African and Caucasian Women
Huisman, Hugo W.; Schutte, Aletta E.; Van Rooyen, Johannes M.; Schutte, Rudolph; Malan, Leoné; Fourie, Catharina M.T.; Malan, Nicolaas T. (Informa Healthcare, 2009)The literature shows an increase in endothelin-1 with increased levels of erythrocytes. There are also indications that inflammation and elevated endothelin-1 levels interact with erythropoiesis. In this study, the association ... -
Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study
Kruger, R.; Schutte, R.; Huisman, H.W.; Van Rooyen, J.M.; Malan, N.T.; Fourie, C.M.T.; Louw, R.; Van der Westhuizen, F.H.; Van Deventer, C.A.; Malan, L.; Schutte, A.E. (Springer Nature, 2012)Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory ... -
Associations of cholesterol and glucose with cardiovascular dysfunction in black Africans: the SABPA study
Lammertyn, Leandi; Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Fourie, Carla M.T.; Malan, Leoné (Informa healthcare, 2011)The aim was to determine whether blood glucose or cholesterol is the more prominent contributor to cardiovascular dysfunction in 101 African men and 99 African women. We measured ambulatory daytime blood pressure (BP), ... -
Asymmetric dimethylarginine and symmetric dimethylarginine prospectively relates to carotid wall thickening in black men: the SABPA study
Mels, Catharina M.C.; Schutte, A.E.; Huisman, H.W.; Smith, W.; Kruger, R.; Van Rooyen, J.M.; Malan, N.T.; Malan, L. (Springer, 2017)The relationship of both asymmetric (ADMA) and symmetric (SDMA) dimethylarginine with carotid wall thickness is inconclusive especially among black populations. We aimed to compare carotid intima media thickness (cIMT) and ... -
Attenuated brain-derived neurotrophic factor and hypertrophic remodelling: the SABPA study
Smith, A.J.; Malan, L.; Uys, A.S.; Malan, N.T.; Harvey, B.H. (Springer Nature, 2015)Brain-derived neurotrophic factor (BDNF) has been linked to neurological pathologies, but its role in cardiometabolic disturbances is limited. We aimed to assess the association between serum BDNF levels and structural ... -
BDNF increases associated with constant troponin T levels and may protect against poor cognitive interference control: the SABPA prospective study
Jansen van Vuren, Esmé; Malan, Leoné; Von Känel, Roland; Lammertyn, Leandi; Malan, Nicolaas T. (Wiley, 2019)Background: Brain‐derived neurotrophic factor (BDNF) modulates brain health and cognition, which can interfere with executive cognitive function. BDNF was impli-cated with microcirculatory ischaemia and may reflect ... -
Blood glutathione and subclinical atherosclerosis in African men: the SABPA study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Szabolcs, Péter; Fourie, Carla M.T.; Van der Westhuizen, Francois H.; Louw, Roan; Botha, Cindy A.; Malan, Leoné (Oxford Univ Press, 2009)Background: Sub-Saharan Africans face an increasing burden of hypertension and related cardiac and cerebrovascular morbidity and mortality, making the identification of factors leading to early vascular abnormalities ... -
Blood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: the SABPA study
Schutte, Aletta E.; Schutte, Rudolph; Huisman, Hugo W.; Van Rooyen, Johannes M.; Fourie, Catharina M.T.; Malan, Nicolaas T.; Malan, Leoné (Nature Publishing Group, 2011)The prognostic significance of blood pressure (BP) variability has lately enjoyed considerable attention. The need for early markers of cardiovascular dysfunction is imperative in black South Africans who have a significant ... -
Brain-derived-neurotrophic-factor, dynamic retinal vessel responses during flicker light and stroke risk: the SABPA study
Wentzel, Annemarie; Malan, Leoné; Von Känel, Roland; Smith, Wayne; Malan, Nicolaas (Karger, 2019)Assessment of the retinal vessels’ structure and function provides an automated and objective approach to noninvasively assess the condition of the cerebral microvasculature and indicates susceptibility for stroke. ... -
A challenged sympathetic system is associated with retinal vascular calibre in a black male cohort: the SABPA Study
Malan, Nicolaas T.; Von Känel, Roland; Smith, Wayne; Lambert, Gavin W.; Vilser, Walthard; Eikelis, Nina; Reimann, Manja; Malan, Leoné (Intech, 2016)Sympathetic system hyperactivity and depression are related to cardiac remodelling in Black men. We investigated whether sympathetic system hyperactivity and depressive symptoms are related to retinal vascular dysregulation. ... -
Chronic defensiveness and neuroendocrine dysfunction reflect a novel cardiac troponin T cut point: the SABPA study
Malan, Leoné; Hamer, Mark; Von Känel, Roland; Steyn, Hendrik S.; Malan, Nicolaas T. (Elsevier, 2017)Background Sympatho-adrenal responses are activated as an innate defense coping (DefS) mechanism during emotional stress. Whether these sympatho-adrenal responses drive cardiac troponin T (cTnT) increases are unknown. ... -
Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: the SABPA study
Malan, Leoné; Hamer, Mark; Von Känel, Roland; Harvey, Brian H.; Steyn, Faans; Malan, Nico T. (Elsevier, 2016)Background Depression has been associated with impaired nitric oxide (NO)-mediated vasodilation and vascular dysregulation (VD). Whether depression and NO levels will disturb retinal haemodynamics is not clear. Objectives ... -
Chronic depression symptoms desensitize renin activity to protect against volume-loading hypertension in Blacks: the SABPA study
De Vos, Arnoldeen C.; Malan, Leoné; Cockeran, Marike; Malan, Nicolaas T.; Seedat, Yackoob K. (Elsevier, 2018)Background Low-renin levels in Blacks have been associated with volume-loading hypertension (HT). Depression symptoms, frequently co-occurring with vascular dysregulation, might reflect a disturbed renin-angiotensin-ald ...