Browsing by Subject "Tuberculous meningitis (TBM)"
Now showing items 1-5 of 5
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Cerebrospinal fluid amino acid profiling of pediatric cases with tuberculous meningitis
(Frontiers Media, 2017)Background: In Africa, tuberculosis is generally regarded as persisting as one of the most devastating infectious diseases. The pediatric population is particularly vulnerable, with infection of the brain in the form of ... -
Metabolic characterization of tuberculous meningitis in a South African paediatric population using 1H NMR metabolomics
(Elsevier, 2020)Objective To better characterize the cerebrospinal fluid (CSF) metabolic profile of tuberculous meningitis (TBM) cases using a South African paediatric cohort. Methods 1H NMR metabolomics was used to analyse the CSF ... -
A metabolomics investigation of tuberculous meningitis in infants and children
(North-West University (South Africa), 2016)This thesis, titled: ‘A metabolomics investigation of Tuberculous Meningitis in infants and children’, deals with tuberculous meningitis (TBM), the most severe complication of tuberculosis (TB) and major pandemic of our ... -
A novel, multi-faceted perception of lactate in neurology
(Frontiers Media, 2020)Lactate has become one of the most re-evaluated metabolites in energy metabolism, particularly as a shuttle in neuroenergetics (Mason, 2017; Ferguson et al., 2018). In a comprehensive review in 2018, Brooks, one of the ... -
A putative urinary biosignature for diagnosis and follow-up of tuberculous meningitis in children: outcome of a metabolomics study disclosing host-pathogen responses
(Springer, 2016)Introduction: Tuberculous meningitis (TBM) is a severe manifestation of tuberculosis, presenting with high morbidity and mortality in children. Existing diagnostic methods for TBM are invasive and time-consuming and the ...