Browsing by Subject "Reversibility"
Now showing items 1-5 of 5
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Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors
(Elsevier, 2013)A series of 4-substituted-2-thiazolylhydrazone derivatives have been synthesized and tested in vitro for their human monoamine oxidase (hMAO) A and B inhibitory activity. Our findings confirmed that the substitution at ... -
An investigation of indanone derivatives as inhibitors of monoamine oxidase
(North-West University (South Africa), Potchefstroom Campus, 2018)MAO-A and MAO-B are two isoforms of mitochondrial monoamine oxidase (MAO) that are responsible for the deamination of various monoamine substrates. For example tyramine and dopamine are metabolised by both MAO isoforms. ... -
SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs
(Taylor & Francis, 2019)The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. ... -
The synthesis and evaluation of benzosuberone derivatives as inhibitors of monoamine oxidase
(North-West University, Potchefstroom Campus, 2018)Monoamine oxidase (MAO) is responsible for the catabolism of neurotransmitters such as serotonin and dopamine in the central nervous system and peripheral tissues. MAO inhibitors such as selegiline play a vital part in the ... -
Synthesis and evaluation of sesamol derivatives as inhibitors of monoamine oxidase
(2014)Parkinson’s disease is an age-related neurodegenerative disorder. The major symptoms of Parkinson’s disease are closely linked to the pathology of the disease. The main pathology of Parkinson’s disease consists of the ...