Browsing by Subject "Rats"
Now showing items 1-8 of 8
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Blood levels of selective antiretroviral drugs over a period of time, in Sprague-Dawley rats
(North-West University, 2008)Selective antiretroviral (ARV) drugs are primarily metabolized by cytochrome P450 (CYP) enzymes, characteristically predisposed to variation, and are therefore primarily responsible for ARV pharmacokinetic variability and ... -
Chemical composition, but not specific surface area, affects calcium retention of nanostructured calcium compounds in growing rats
(Oxford Univ Press, 2017)Background: Low dietary calcium intake and bioavailability may adversely affect bone health. Reducing the size of calcium compounds increases their specific surface area (SSA, expressed as m2/g) and may increase calcium ... -
Effects of dieatry onion (Allium cepa L.) in a rodent model of high-fat diet streptozotocin-induced diabetes
(Karger, 2008)Background/Aims: The present study was conducted to investigate the effects of two dietary doses of freeze-dried onion powder on diabetes-related symptoms in a high-fat (HF) diet streptozotocin (STZ)-induced diabetes rat ... -
Experimental rodent models of type 2 diabetes: a review
(Thomson Reuters, 2009)Due to the high prevalence of diabetes worldwide, extensive research is still being performed to develop new antidiabetic agents and determine their mechanisms of action. Consequently, a number of diabetic animal models ... -
An optimized method for the analysis of corticosterone in rat plasma by UV-HPLC
(Society of Medical Laboratory Technologists of SA, 2012)Animal models are useful in the study of stress disorders in that they offer the possibility of stimulating a human condition under controlled conditions in a simpler, more readily understandable system. Stress-related ... -
A pharmacokinetic-pharmacodynamic relationship study between GABA-ergic drugs and anxiety levels in an animal model of PTSD
(North-West University, 2005)Posttraumatic stress disorder (PTSD) is classified as an anxiety disorder and the characteristic symptoms (re-experiencing, avoidance as well as numbing of general responsiveness and hyperarousal) of this disorder develop ... -
The role of monoamines in post traumatic stress disorder (PTSD) using a time dependent sensitization animal model
(North-West University, 2004)Posttraumatic stress disorder (PTSD) is an anxiety disorder that may result from an exposure to a severely traumatic life-event. It is characterised by a delayed onset of psychological and physical symptoms including ... -
The schizophrenia and bipolar disorder associated BRD1 gene is regulated upon chronic restraint stress
(Elsevier, 2012)Recent genetic evidence has implicated the bromodomain containing 1 gene (BRD1) with brain development and susceptibility to Schizophrenia and Bipolar Disorder. The BRD1 protein, which is essential for acetylation of histone ...