Browsing by Subject "Pheroid™"

Now showing items 1-10 of 11

    • Essential fatty acids as transdermal penetration enhancers 

      Van Zyl, Lindi; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta; Viljoen, Joe (Elsevier, 2016)
      The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F and Pheroid™ ...

    • Evaluation and validation of in vitro assays to determine cell viability for HIV/AIDS expermentation with Pheroid TM technology 

      Van der Merwe, Helanie (North-West University, 2008)
      The Southern parts of Africa have the highest prevalence of HIV-infected people and South Africa is the country with the highest number of infections in the world. There is still no cure for AIDS, but anti-HIV medicine can ...

    • Exploratory data analysis of the dependencies between skin permeability, molecular weight and log P 

      Kilian, D.; Lemmer, H.J.R.; Gerber, M.; Du Preez, J.L.; Du Plessis, J. (Govi-Verlag, 2016)
      Molecular weight and log P remain the most frequently used physicochemical properties in models that predict skin permeability. However, several reports over the past two decades have suggested that predictions made by ...

    • Formulation and evaluation of different transdermal delivery systems with flurbiprofen as marker 

      Van Zyl, Lindi (North-West University, 2012)
      The aim of this study was to investigate the effect of different penetration enhancers containing essential fatty acids (EFAs) on the transdermal delivery of flurbiprofen. Flurbiprofen was used as a marker / model compound. ...

    • Formulation and topical delivery of lidocaine and prilocaine with the use of Pheroid™ technology 

      Nell, Dirkie Cornelia (North-West University, 2012)
      Local anaesthetics are used regularly in the medical world for a variety of different procedures. Topical anaesthetics are used largely in minor skin breaking procedures, laceration repair and minor surgical procedures ...

    • Optimised topical delivery of 5–fluorouracil 

      Chinembiri, Tawona Nyasha (North-West University, 2012)
      Skin cancer is the most widely diagnosed form of cancer and it is split in to non-melanoma skin cancer (NMSC) and cutaneous malignant melanoma (CMM). Cutaneous melanoma has a high propensity for malignancy and it has the ...

    • Pheroid® technology in the transdermal delivery of selected non-steroidal anti-inflammatory drugs 

      Kilian, Dewald (North-West University (South Africa) , Potchefstroom Campus, 2015)
      Drug delivery through the skin still remains an area that enjoys active research with much of the research focusing on physical or chemical methods to reversibly alter the skin’s permeability to compounds because of the ...

    • Synthesis and transdermal penetration of stavudine-5'-esters. 

      Holmes, Estee-Marie; Breytenbach, Jaco C.; Gerber, Minja; Du Plessis, Jeanetta (Bentham Science, 2010)
      The aim of this study was to investigate the effects of different ester groups in position 5’ of stavudine on the transdermal penetration with and without the use of Pheroid™ as the delivery system. Six esters were prepared ...

    • Topical and transdermal delivery of L-carnitine 

      Fox, L.T.; Gerber, M.; Grobler, A.; Du Preez, J.L.; Du Plessis, J. (Karger, 2011)
      Background: The two types of skin aging (intrinsic and extrinsic) share important molecular features, while having distinct differences on the macromolecular level: both lead to increased production of reactive oxygen ...

    • Topical delivery of acyclovir and ketoconazole 

      Jacobs, Gerda A.; Gerber, Minja; Malan, Maides M.; Du Preez, Jan L.; Fox, Lizelle T.; Du Plessis, Jeanetta (Taylor & Francis, 2014)
      Context: Viral and fungal cutaneous manifestations are regularly encountered in immunocompromised HIV/AIDS individuals and can be treated by drugs such as acyclovir and ketoconazole, respectively. Objective: The aim of ...