Browsing by Subject "Phenotyping"
Now showing items 1-3 of 3
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Genetic polymorphism in dextromethorphan metabolism by CYP2D6 and CYP3A4 enzyme isoforms
(North-West University, 2003)Most administered drugs are metabolised in the liver by Phase I enzymes and more importantly by the cytochrome P450 (CYP) system. The extent of first-pass metabolism is important in determining whether the drug will have ... -
Investigation into the protection of mitochondrial disease pathology by metallothionein overexpression
(North-West University (South Africa), 2020)Mitochondrial diseases (MD), such as Leigh Syndrome (LS), present with severe neurological and muscular phenotypes in patients, but have no known cure and limited treatment options. Based on their neuroprotective effects ... -
Metallothionein 1 overexpression does not protect against mitochondrial disease pathology in Ndufs4 knockout mice
(Springer, 2021)Mitochondrial diseases (MD), such as Leigh syndrome (LS), present with severe neurological and muscular phenotypes in patients, but have no known cure and limited treatment options. Based on their neuroprotective effects ...