Browsing by Subject "Neuroprotection"
Now showing items 1-8 of 8
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Aminopyrimidine derivatives as adenosine antagonists
(2013)Aims of this project - The aim of this study was to design and synthesise novel 2-aminopyrimidine derivatives as potential adenosine A1 and A2A receptor antagonists. Background and rationale - Parkinson’s disease is the ... -
Antioxidant properties of 4-quinolones and structurally related flavones
(Elsevier, 2012)Neurodegenerative disorders are frequently associated with increased oxidative damage to the brain as a result of free radicals produced by cellular respiration. The onset and progression of neurodegeneration may therefore ... -
Fluorescent polycyclic ligands : strategies towards the synthesis and evaluation of fluorescently labelled receptor and enzyme ligands
(North-West University, 2012)Neurodegenerative disorders, including Alzheimer's and Parkinson's disease, and the development of neuroprotective agents have received significant research attention in recent years. Development of novel imaging techniques ... -
Fluorescent polycyclic ligands for nitric oxide synthase (NOS) inhibition
(Elsevier, 2008)In recent years polycyclic compounds have been shown to exhibit pharmacological profiles of importance in the symptomatic and proposed curative treatment of neurodegenerative diseases (e.g., Parkinson’s and Alzheimer’s ... -
The modulating effect of sildenafil on cell viability and on the function of selected pharmacological receptors in cell cultures
(North-West University, 2004)Since sildenafil's (Viagra®), a phospodiesterase type 5 (PDE5) inhibitor, approval for the treatment of male erectile dysfunction (MED) in the United States early 1998, 274 adverse event reports were filed by the Food and ... -
Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents
(Elsevier, 2014)The aim of this study was to design drug-like molecules with multiple neuroprotective mechanisms which would ultimately inhibit N-methyl-D-aspartate (NMDA) receptors, block L-type voltage gated calcium channels (VGCC) ... -
S-nitrosylation and attenuation of excessive calcium flux by pentacycloundecane derivatives
(Bentham Science, 2012)A novel series of polycyclic amines, containing nitrogen monoxide donating moieties, were synthesised and tested for calcium channel and N-methyl-D-aspartate receptor modulating activity. The synthesised compounds were ... -
Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents
(Elsevier, 2011)A series of fluorescent heterocyclic adamantane amines were synthesised with the goal to develop novel fluorescent ligands for neurological assay development. These derivatives demonstrated multifunctional neuroprotective ...