Browsing by Subject "Method validation"
Now showing items 1-4 of 4
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Development and validation of a LC-MS/MS method for the quantitation of lumefantrine in mouse whole blood and plasma
(Elsevier, 2015)A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for the quantitation of the antimalarial drug, lumefantrine (LF), in mouse whole blood and plasma. The analyte was extracted ... -
Development and validation of an LC-MS/MS method for the quantification of goserelin in a Pheroid (R) formulation, in simulated intestinal fluid
(Elsevier, 2020)The purpose of this reported study was to develop and validate an LC-MS/MS method for the quantification of goserelin in a Pheroid (R) formulation simulated intestinal fluid. Biopharmaceuticals are formulated in drug ... -
Development of a bioanalytical method for the quantitative analysis of cannabinoids and their metabolites in plasma
(North-West University (South-Africa), 2020)There is a continuous need to develop sensitive analytical methods for detection of cannabinoids and their metabolites in human plasma for forensic purposes as well as for pharmacokinetics studies. Liquid chromatography ... -
Re-assessment and optimisation of an organic acid extraction method for automation
(North-West University (South Africa), Potchefstroom Campus, 2017)Sample preparation is a necessary prerequisite for GC/MS analysis of urinary organic acids for clinical diagnosis of inborn errors of metabolism (IEM). The sample clean-up step in the analytical process poses a challenge. ...