Browsing by Subject "Insulin"
Now showing items 1-10 of 14
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Cardiovascular dysfunction in black South Africans: an investigation from various perspectives
(North-West University, 2010)Motivation: The prevalence of cardiovascular dysfunction, especially hypertension, in Africans has increased dramatically over the past few decades. Despite considerable in- depth studies, cardiovascular diseases remain ... -
Development and evaluation of a double-phase multiple-unit dosage form for enhanced insulin intestinal delivery
(Bentham Science, 2018)Background: The oral route is the most preferred route of administration for selfmedication, but poor membrane permeability and pre-systemic degradation are key challenges that need to be addressed. Objective: The purpose ... -
Development of a double phase dosage form for enhanced peptide drug delivery
(2015)Parenteral administration remains the most utilised route of administration for therapeutic peptides due to low intestinal epithelial permeability. However, the most convenient and popular route of drug administration ... -
Dietary calcium intake and obesity in adult women : the POWIRS study
(North-West University, 2004)Background: The role of dietary calcium in weight management is gaining support in the nutrition research community. It has been hypothesized that high calcium diets protect against fat gain by creating a balance of lipolysis ... -
The effect of the glycaemic index of a pre-exercise meal on the glycaemic and insulin responses during acute exercise
(North-West University (South-Africa), 1999)Introduction : The objectives of this study were to examine the role of the glycaemic index of a pre-exercise meal, ingested 1 hour before an acute exercise test (15 -20 min), on the metabolic profile of elite athletes ... -
Eudragit® L100/N-trimethylchitosan chloride microspheres for oral insulin delivery
(MDPI, 2013)Effective oral delivery of protein and peptide drugs remains an active topic in scientific research. In this study, matrix type microspheres were prepared with Eudragit® L100 containing N-trimethylchitosan chloride to ... -
Gastrointestinal region specific insulin absorption enhancement by Aloe vera leaf materials
(North-West University (South Africa) , Potchefstroom Campus, 2015)The oral administration route is still the most popular and preferred route for drug administration, but is, however, not suitable for protein and peptide drugs such as insulin, due to their poor bioavailability when ... -
Gastrointestinal region specific insulin permeation enhancement by Aloe vera gel
(Bentham Science, 2020)Background: The oral administration route is still the most preferred by patients for drug treatment, but is unfortunately not suitable for all drug compounds. For example, protein and peptide drugs (e.g. insulin) are ... -
Metabolic energy management and cancer
(North-West University, 2007)This study examined the energy dependence of cancer cells. Glucose was found to be their main energy source. It seems possible to use this dependence to advantage in the fight against cancer. A novel experiment to reduce ... -
The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour
(Taylor & Francis, 2018)Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA). Objective: We ...