Browsing by Subject "In vitro models"
Now showing items 1-3 of 3
-
Comparison of rat and porcine jejunum as in vitro models for P–glycoprotein mediated efflux using the Sweetana–Grass diffusion method
(North-West University, 2010)Absorption of drug substances across the intestinal epithelium is a complex and dynamic process. Counter transport proteins are responsible for the efflux of specific drug molecules after they have been absorbed. One of ... -
Establishing three-dimensional cell culture models to measure biotransformation and toxicity
(North-West University, Potchefstroom Campus, 2018)A great proportion of new chemical entities will be terminated from the clinical drug development pipeline as a result of deficiencies in drug absorption, distribution, biotransformation and elimination as well as potential ... -
Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective
(Taylor & Francis, 2018)The liver is a vital organ fulfilling a central role in over 500 major metabolic functions, including serving as the most essential site for drug biotransformation. Dysfunction of the drug biotransformation processes may ...