Browsing by Subject "Hybrids"
Now showing items 1-6 of 6
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Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives
(Wiley, 2019)Tuberculosis is the deadliest infectious disease affecting humankind with a death toll of approximately 1.7 million people in 2016. The increasing prevalence of multidrug‐resistant strains of the causative pathogen, ... -
Synthesis and antimalarial activity screening of artemisinin-acridine hybrids
(2013)Malaria endemic areas not only pose a public health threat, but affects 3.3 billion people worldwide. In 2011, estimated malaria related deaths amounted to 660 000 out of 219 million reported cases, with 81% of these and ... -
Synthesis and in vitro biological evaluation of aminoacridines and artemisinin-acridine hybrids
(Elsevier, 2014)During this study, 9-aminoacridine and artemisinin–acridine hybrid compounds were synthesized and the in vitro for antimalarial activity against both the chloroquine sensitive but also gametocytocidal strain (NF54), and ... -
Synthesis, cytotoxicity and antiplasmodial activity of novel ferrocenyl-artemisinin hybrids
(North-West University (South-Africa). Potchefstroom Campus, 2019)Malaria is caused by a parasite of the genus Plasmodium. Of the five species that infect humans, Plasmodium falciparum is the most dangerous. This disease caused 435 thousand deaths in 2017. It is estimated that 266 thousand ... -
Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids
(Elsevier, 2011)Dihydroartemisinin (DHA) was coupled to different aminoquinoline moieties forming hybrids 9–14, which were then treated with oxalic acid to form oxalate salts (9a–14a). Compounds 9a, 10a, 12, 12a, and 14a showed comparable ... -
Triazole-linked 1,4-naphthoquinone derivatives : synthesis and antiplasmodial activity
(North-West University (South-Africa). Potchefstroom Campus, 2019)Malaria is a protozoan disease transmitted to humans through female Anopheles mosquitoes. The malaria parasite thrives in tropical areas, thus people there are at higher risk, especially in third-world countries like ...