Browsing by Subject "Excipients"
Now showing items 1-6 of 6
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Application of halloysite clay nanotubes as a pharmaceutical excipient
(Elsevier, 2017)Halloysite nanotubes, a biocompatible nanomaterial of 50–60 nm diameter and ca. 15 nm lumen, can be used for loading, storage and sustained release of drugs either in its pristine form or with additional polymer complexation ... -
Effects of selected pharmaceutical excipients on drug permeation at different gastro-intestinal tract regions
(North-West University (South Africa) , Potchefstroom Campus, 2016)Although pharmaceutical excipients are considered pharmacologically inert, some excipients in dosage forms have shown an effect on the pharmacokinetics of certain drugs. This could be due to different mechanisms such as ... -
Investigation of the stabilising effects of niosomes on the amorphous forms of roxithromycin
(North-West University (South Africa), Potchefstroom Campus, 2018)The first aim of this research study was to determine the effect of the excipients used in the typical niosome preparation on the solid-state nature of three solid-state forms of roxithromycin. The second aim was to ascertain ... -
Prediction of compressibility of pharmaceutical excipients in solid oral dosage forms
(North-West University (South Africa) , Potchefstroom Campus, 2016)Tablets are one of the most preferred dosage forms for patients, but pre-formulation studies for tablets are often time consuming and expensive. The SeDeM Expert Diagram System attempts to address this problem by decreasing ... -
The role of functional excipients in solid oral dosage forms to overcome poor drug dissolution and bioavailability
(MDPI, 2020)Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The oral bioavailability of these compounds ... -
The SeDeM expert diagram system: its performance and predictability in direct compressible formulations containing novel excipients and different types of active ingredients
(Elsevier, 2017)The SeDeM Expert Diagram System is a galenic pre-formulation system, which evaluates the suitability of excipients and active pharmaceutical ingredients (API's) for direct compression into tablets as well as predicting ...