Browsing by Subject "Epigenetics"
Now showing items 1-8 of 8
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An analysis of the effect of transformation on global– and gene–specific DNA methylation in four cultured cell lines
(North-West University, 2010)DNA methylation plays a role in several biological functions, such as gene expression regulation, and several endogenous and exogenous factors affect these DNA methylation patterns in the cell. One such alteration of a ... -
Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene
(Oxford Univ Press, 2015)Background: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has ... -
DNA methylation associated with mitochondrial dysfunction in a south african autism spectrum disorder cohort
(Wiley, 2020)Autism spectrum disorder (ASD) is characterized by phenotypic heterogeneity and a complex genetic architecture which includes distinctive epigenetic patterns. We report differential DNA methylation patterns associated with ... -
Levels of DNA methylation and transcript accumulation in leaves of transgenic maize varieties
(Springer, 2016)Background: Prior to their release in the environment, transgenic crops are examined for their health and environ‑ mental safety. In addition, transgene expression needs to be consistent in order to express the introduced ... -
Methylation vs. protein inflammatory biomarkers and their associations with cardiovascular function
(Frontiers Media, 2020)DNA methylation data can be used to estimate proportions of leukocyte subsets retrospectively, when directly measured cell counts are unavailable. The methylation-derived neutrophil-to-lymphocyte and lymphocyte-to-monocyte ... -
MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro
(Oxford Univ Press, 2016)Background: MicroRNAs (miRNAs) are small regulatory molecules that cause translational repression by base pairing with target mRNAs. Cumulative evidence suggests that changes in miRNA expression may in part underlie the ... -
Neuroprogression in schizophrenia: pathways underpinning clinical staging and therapeutic corollaries
(Sage, 2014)Objective: Whilst dopaminergic dysfunction remains a necessary component involved in the pathogenesis of schizophrenia, our current pharmacological armoury of dopamine antagonists does little to control the negative ... -
One year exposure to Cd- and Pb-contaminated soil causes metal accumulation and alteration of global DNA methylation in rats
(Elsevier, 2019)Metal pollution has been associated with anthropogenic activities, such as effluents and emissions from mines. Soil could be exposure route of wild rats to metals, especially in mining areas. The aim of this study was to ...