Browsing by Subject "Efavirenz"
Now showing items 1-9 of 9
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Bio-behavioural evaluation of efavirenz and Δ9-tetrahydrocannabinol alone and in combination in rats with respect to psychosis and anxiety
(North-West University (South-Africa), 2019)The highly active antiretroviral therapy, efavirenz (EFV), has been noted to occur as a constituent of a potent new designer drug cocktail called “Nyaope” or “Whoonga”, which is reported to have mind-altering and addictive-like ... -
CYP2B6 haplotype predicts efavirenz plasma concentration in black South African HIV-1-infected children: a longitudinal pediatric pharmacogenomic study
(Mary Ann Liebert, 2017)South Africa has the highest burden of the human immunodeficiency virus (HIV) infection globally. Efavirenz (EFV), a frequently used drug against HIV infection, displays a relationship between drug concentration and ... -
Determination of salivary efavirenz by liquid chromatography coupled with tandem mass spectrometry
(Elsevier, 2010)A novel and robust screening method for the determination of the non-nucleoside reverse transcriptase inhibitor, efavirenz (EFV), in human saliva has been developed and validated based on high performance liquid chromatography ... -
The development of efavirenz and praziquantel amorphous solid dispersions
(North-West University (South-Africa), 2019)Many active pharmaceutical ingredients (API) that are highly permeable, have low aqueous solubility. Such APIs are classified as Biopharmaceutics classification system (BCS) class II drugs. Efavirenz and praziquantel both ... -
Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon–caprolactone) nanoparticles by a spray–drying method
(NCBI, 2014)AIM: To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. MATERIALS & METHODS: EFV-loaded ... -
Evaluation of efavirenz on neurochemical and oxidative stress markers and addictive-like behaviours in rats
(North-West University, 2018)HIV positive patients treated with the antiretroviral (ARV) drug efavirenz have been observed to experience various neuropsychiatric symptoms including insomnia, dizziness, somnolence, vivid and abnormal dreams and thoughts ... -
Influence of CYP2B6 516G>T polymorphism and interoccasion variability (IOV) on the population pharmacokinetics of efavirenz in HIV-infected South African children
(Springer, 2012)Objective To investigate the influence of CYP2B6 516G>T polymorphism, as a covariate, and of interoccasion variability (IOV) on the oral clearance (CL/F) of efavirenz (EFV) in treatment-naïve black South African children ... -
Population pharmacokinetic and pharmacodynamic study of efavirenz in HIV–1–infected children treated with first line antiretroviral therapy in South Africa
(North-West University, 2011)Highly active antiretroviral therapy (HAART) has improved the life expectancy of HIV–1–infected patients dramatically since it was launched in 1996, but there are still many challenges in the provision of HAART, especially ... -
Quality and safety implications of efavirenz and pyrimethamine crystal modifications
(2014)This study focused on two active pharmaceutical ingredients (APIs) that are used to treat two of the most notorious diseases in Africa, i.e. human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) and ...