Browsing by Subject "Dissolution"
Now showing items 1-10 of 25
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All-atomistic molecular dynamics (AA-MD) studies and pharmacokinetic performance of PAMAM-dendrimer-furosemide delivery systems
(Elsevier, 2018)Improvement of problematic dissolution and solubility properties of a model drug, furosemide, was investigated for poly(amidoamine) (PAMAM) dendrimer complexes of the drug. Full and half generation dendrimers with amino ... -
Amorphism and polymorphism of azithromycin
(North-West University, 2012)Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ... -
Amorphous azithromycin with improved aqueous solubility and intestinal membrane permeability
(Taylor & Francis, 2015)Azithromycin (AZM) is a poorly soluble macrolide antibacterial agent. Its low solubility is considered as the major contributing factor to its relatively low oral bioavailability. The aim of this study was to improve the ... -
Characterization of polymorph transformations that decrease the stability of tablets containing the who essential drug mebendazole
(Elsevier, 2010)This study investigated the influence of moisture and heat on the stability of mebendazole polymorph C in tablets. The polymorphic forms of mebendazole display significant differences in solubility and therapeutic efficacy ... -
Chemical composition, but not specific surface area, affects calcium retention of nanostructured calcium compounds in growing rats
(Oxford Univ Press, 2017)Background: Low dietary calcium intake and bioavailability may adversely affect bone health. Reducing the size of calcium compounds increases their specific surface area (SSA, expressed as m2/g) and may increase calcium ... -
The development of efavirenz and praziquantel amorphous solid dispersions
(North-West University (South-Africa), 2019)Many active pharmaceutical ingredients (API) that are highly permeable, have low aqueous solubility. Such APIs are classified as Biopharmaceutics classification system (BCS) class II drugs. Efavirenz and praziquantel both ... -
Development of multiple-unit pellet system tablets by employing the SeDeM expert diagram system. II. Pellets containing different active pharmaceutical ingredients
(Taylor & Francis, 2019)The SeDeM Expert Diagram System (SeDeM EDS) was originally developed to provide information about the suitability of powders to produce direct compressible tablets. Multiple-unit pellet systems (MUPS) are dosage forms ... -
The development of paracetamol and dapsone amorphous solid dispersions
(North-West University (South-Africa), 2021)The development of APIs was focused on the crystalline form over the years, but as the poor solubility of new drugs increased, the focus turned to developing the amorphous form of the drug. Dapsone (DAP) is no exception, ... -
The development of ritonavir and pyrimethamine amorphous solid dispersions
(North-West University (South-Africa), 2021)Poorly soluble drugs are a major problem in the pharmaceutical industry. Not only does it lead to formulation difficulties, but it also leads to poor absorption and poor bioavailability of drugs. Ritonavir (RTV) is a ... -
The development of sulfadoxine and nevirapine pharmaceutical amorphous solid dispersions
(North-West University (South-Africa), 2019)Solid oral dosage forms are the most convenient and prevalent dosage form in the pharmaceutical industry although an estimated 90% of drugs currently in development can be classified as poorly soluble. These drugs will ...