Browsing by Subject "Cell culture"
Now showing items 1-5 of 5
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An analysis of the effect of transformation on global– and gene–specific DNA methylation in four cultured cell lines
(North-West University, 2010)DNA methylation plays a role in several biological functions, such as gene expression regulation, and several endogenous and exogenous factors affect these DNA methylation patterns in the cell. One such alteration of a ... -
Metabolomics reveals the depletion of intracellular metabolites in HepG2 cells after treatment with gold nanoparticles
(Taylor & Francis, 2018)Studies on the safety of gold nanoparticles (GNPs) are plentiful due to their successful application in drug delivery and treatment of diseases in trials. Cytotoxicity caused by GNPs has been studied on the physiological ... -
Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux
(Springer, 2019)Purpose Efflux transporters of the adenosine triphosphate-binding cassette (ABC)-superfamily play an important role in the development of multidrug resistance (multidrug resistant; MDR) in cancer. The overexpression of ... -
Optimised topical delivery of 5–fluorouracil
(North-West University, 2012)Skin cancer is the most widely diagnosed form of cancer and it is split in to non-melanoma skin cancer (NMSC) and cutaneous malignant melanoma (CMM). Cutaneous melanoma has a high propensity for malignancy and it has the ... -
A quantitative assessment of cell-free DNA utilizing several housekeeping genes: measurements from four different cell lines
(Springer, 2016)Quantitative real-time PCR (qPCR) is regularly used to quantify cell-free nucleic acids (cfNAs) in order to identify biomarkers for various pathologies. However, studies have shown notable housekeeping gene expression ...